HitPredict

Interactor 1: UB2L6 (O14933)
Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L6) (Retinoic acid-induced gene B protein) (RIG-B) (UbcH8) (Ubiquitin carrier protein L6) (Ubiquitin-protein ligase L6)
Gene: UBE2L6

Interactor 2: UBA1 (P22314)
Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1)
Gene: UBA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	9153201, 30097011
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	E1_UFD~UQ_con, ThiF~UQ_con
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 153 Hs			1 1058
+	Hs
		607190 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		UBA1_HUMAN (1-1058): 0: 1358: 100.00
+	Hs
		607026 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		UBA1_HUMAN (1-1058): 0: 1358: 100.00
+	Hs
		607050 UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58		UBA1_HUMAN (1-1058): 0: 1358: 100.00
+	Hs
		607039 UB2D3_HUMAN (2-149): 5.99e-74: 219: 36.24		UBA1_HUMAN (1-1058): 0: 1358: 100.00
+	Hs
		607136 UB2E2_HUMAN (3-148): 7.71e-69: 208: 32.65		UBA1_HUMAN (1-1058): 0: 1358: 100.00
+	Hs
		607129 UB2E3_HUMAN (3-148): 1.55e-68: 207: 31.97		UBA1_HUMAN (1-1058): 0: 1358: 100.00
+	Hs
		607028 UB2E1_HUMAN (3-148): 5.11e-67: 203: 34.01		UBA1_HUMAN (1-1058): 0: 1358: 100.00
+	Hs
		607057 UB2L3_HUMAN (1-152): 6.11e-66: 199: 55.26		UBA1_HUMAN (1-1058): 0: 1358: 100.00
+	Hs
		48080 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		UBA6_HUMAN (12-1057): 0: 1037: 41.09
+	Sp
		293848 UBC4_SCHPO (2-148): 4.92e-74: 219: 36.49		UBA1_SCHPO (36-1053): 0: 1080: 53.37
+	Hs
		159028 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		UBA7_HUMAN (41-1057): 0: 1006: 46.00
+	Sc
		549788 UBC4_YEAST (1-148): 7.47e-75: 221: 36.91		UBA1_YEAST (38-1057): 0: 1063: 51.50
+	Hs
		48104 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		UBA6_HUMAN (12-1057): 0: 1037: 41.09
+	Hs
		48107 UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58		UBA6_HUMAN (12-1057): 0: 1037: 41.09
+	Hs
		48106 UB2D3_HUMAN (2-149): 5.99e-74: 219: 36.24		UBA6_HUMAN (12-1057): 0: 1037: 41.09
+	Hs
		48108 UB2L3_HUMAN (1-152): 6.11e-66: 199: 55.26		UBA6_HUMAN (12-1057): 0: 1037: 41.09
+	Hs
		782203 UB2E1_HUMAN (3-148): 5.11e-67: 203: 34.01		UBA7_HUMAN (41-1057): 0: 1006: 46.00
+	Hs
		782206 UB2L3_HUMAN (1-152): 6.11e-66: 199: 55.26		UBA7_HUMAN (41-1057): 0: 1006: 46.00
+	Hs
		1282360 UB2E3_HUMAN (3-148): 1.55e-68: 207: 31.97		SAE2_HUMAN (60-451): 2.55e-88: 299: 17.08
+	Hs
		919796 UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58		UBA3_HUMAN (847-1018): 1.74e-12: 72.9: 17.13