HitPredict

Interactor 1: UB2L6 (O14933)
Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L6) (Retinoic acid-induced gene B protein) (RIG-B) (UbcH8) (Ubiquitin carrier protein L6) (Ubiquitin-protein ligase L6)
Gene: UBE2L6

Interactor 2: R144A (P50876)
E3 ubiquitin-protein ligase RNF144A (EC 2.3.2.31) (RING finger protein 144A) (UbcM4-interacting protein 4) (Ubiquitin-conjugating enzyme 7-interacting protein 4)
Gene: RNF144A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.791

Property	Details
Experiments	19549727, 11722579
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	IBR~UQ_con
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0000209 - protein polyubiquitination GO:0005737 - cytoplasm GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 153 Hs			1 292
+	Hs
		159069 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		R144B_HUMAN (3-285): 2.41e-87: 264: 54.77
+	Hs
		159096 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		RN19A_HUMAN (16-276): 5.96e-75: 246: 25.00
+	Hs
		159068 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		RN19B_HUMAN (13-276): 3.98e-73: 240: 25.54
+	Hs
		842095 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		R144A_HUMAN (1-292): 5.59e-97: 288: 100.00
+	Hs
		842104 UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58		R144A_HUMAN (1-292): 5.59e-97: 288: 100.00
+	Hs
		159108 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		ARI1_HUMAN (14-229): 1.58e-64: 213: 27.35
+	Hs
		159008 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		ARI2_HUMAN (2-231): 1.5e-64: 211: 25.53
+	Hs
		919757 UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58		RN19B_HUMAN (13-276): 3.98e-73: 240: 25.54
+	Hs
		849498 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		ARI1_HUMAN (14-229): 1.58e-64: 213: 27.35
+	Hs
		312679 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		ARI2_HUMAN (2-231): 1.5e-64: 211: 25.53
+	Hs
		312520 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		ARI2_HUMAN (2-231): 1.5e-64: 211: 25.53
+	Hs
		312553 UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58		ARI2_HUMAN (2-231): 1.5e-64: 211: 25.53
+	Hs
		1354303 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		RNF14_HUMAN (14-239): 1.82e-59: 198: 22.93
+	Hs
		849474 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		RNF14_HUMAN (14-239): 1.82e-59: 198: 22.93
+	Hs
		1290106 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		RNF31_HUMAN (19-218): 8.15e-50: 178: 23.04
+	Hs
		849403 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		RNF31_HUMAN (19-218): 8.15e-50: 178: 23.04
+	Hs
		919819 UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58		RNF31_HUMAN (19-218): 8.15e-50: 178: 23.04
+	Hs
		159097 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		RN216_HUMAN (17-219): 3.83e-12: 68.6: 27.54
+	Hs
		1347205 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		RN216_HUMAN (17-219): 3.83e-12: 68.6: 27.54
+	Hs
		849460 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		RN216_HUMAN (17-219): 3.83e-12: 68.6: 27.54