HitPredict

Interactor 1: UB2L6 (O14933)
Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L6) (Retinoic acid-induced gene B protein) (RIG-B) (UbcH8) (Ubiquitin carrier protein L6) (Ubiquitin-protein ligase L6)
Gene: UBE2L6

Interactor 2: UBE3A (Q05086)
Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)
Gene: UBE3A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	9153201, 17433363
Identification Methods	enzymatic study, fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0000209 - protein polyubiquitination GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 153 Hs			1 875
+	Hs
		849311 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		UBE3A_HUMAN (1-875): 0: 1058: 100.00
+	Hs
		159031 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		NEDD4_HUMAN (46-873): 0: 622: 21.49
+	Hs
		125000 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		WWP2_HUMAN (291-873): 0: 589: 24.72
+	Hs
		159084 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		ITCH_HUMAN (325-873): 0: 579: 24.78
+	Hs
		159085 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		NED4L_HUMAN (247-873): 0: 575: 22.52
+	Hs
		808052 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		NEDD4_HUMAN (46-873): 0: 622: 21.49
+	Hs
		159100 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		HERC5_HUMAN (153-873): 1.77e-175: 536: 23.20
+	Hs
		125808 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		WWP2_HUMAN (291-873): 0: 589: 24.72
+	Hs
		125262 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		WWP2_HUMAN (291-873): 0: 589: 24.72
+	Hs
		159074 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		HERC6_HUMAN (151-872): 1.74e-172: 528: 24.09
+	Hs
		849333 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		HERC3_HUMAN (139-874): 0: 582: 26.85
+	Hs
		1294888 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		ITCH_HUMAN (325-873): 0: 579: 24.78
+	Hs
		849411 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		ITCH_HUMAN (325-873): 0: 579: 24.78
+	Hs
		849416 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		NED4L_HUMAN (247-873): 0: 575: 22.52
+	Hs
		849444 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		WWP1_HUMAN (185-873): 0: 560: 22.22
+	Hs
		849451 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		SMUF2_HUMAN (334-872): 0: 554: 24.79
+	Hs
		849452 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		SMUF1_HUMAN (405-872): 1.32e-175: 528: 27.04
+	Hs
		159070 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97
+	Hs
		849353 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97
+	Hs
		849334 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		UBE3C_HUMAN (453-872): 2.23e-52: 200: 32.27