HitPredict

Interactor 1: UB2L6 (O14933)
Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L6) (Retinoic acid-induced gene B protein) (RIG-B) (UbcH8) (Ubiquitin carrier protein L6) (Ubiquitin-protein ligase L6)
Gene: UBE2L6

Interactor 2: HERC6 (Q8IVU3)
Probable E3 ubiquitin-protein ligase HERC6 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 6) (HECT-type E3 ubiquitin transferase HERC6)
Gene: HERC6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 153 Hs			1 1022
+	Hs
		159100 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		HERC5_HUMAN (2-1014): 0: 916: 47.95
+	Hs
		849333 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		HERC3_HUMAN (2-1014): 0: 945: 37.76
+	Hs
		849478 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		HERC5_HUMAN (2-1014): 0: 916: 47.95
+	Hs
		159084 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		ITCH_HUMAN (508-1014): 0: 579: 19.39
+	Hs
		159031 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		NEDD4_HUMAN (566-1014): 3.48e-179: 559: 21.73
+	Hs
		125000 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		WWP2_HUMAN (325-1014): 0: 554: 16.92
+	Hs
		159085 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		NED4L_HUMAN (566-1014): 3.26e-179: 549: 23.47
+	Hs
		159052 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		UBE3A_HUMAN (402-1014): 1.36e-175: 536: 24.49
+	Hs
		1294888 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		ITCH_HUMAN (508-1014): 0: 579: 19.39
+	Hs
		849411 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		ITCH_HUMAN (508-1014): 0: 579: 19.39
+	Hs
		808052 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		NEDD4_HUMAN (566-1014): 3.48e-179: 559: 21.73
+	Hs
		849444 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		WWP1_HUMAN (515-1014): 0: 556: 19.62
+	Hs
		125808 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		WWP2_HUMAN (325-1014): 0: 554: 16.92
+	Hs
		125262 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		WWP2_HUMAN (325-1014): 0: 554: 16.92
+	Hs
		849351 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		HECW1_HUMAN (461-1014): 2.59e-174: 553: 20.11
+	Hs
		849416 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		NED4L_HUMAN (566-1014): 3.26e-179: 549: 23.47
+	Hs
		849311 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		UBE3A_HUMAN (402-1014): 1.36e-175: 536: 24.49
+	Hs
		849451 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		SMUF2_HUMAN (513-1014): 9.06e-175: 530: 20.93
+	Hs
		849452 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		SMUF1_HUMAN (548-1014): 1.29e-164: 504: 21.65
+	Hs
		319766 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		HERC2_HUMAN (699-1009): 8.5e-15: 82: 26.89