HitPredict

Interactor 1: UB2L6 (O14933)
Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L6) (Retinoic acid-induced gene B protein) (RIG-B) (UbcH8) (Ubiquitin carrier protein L6) (Ubiquitin-protein ligase L6)
Gene: UBE2L6

Interactor 2: NED4L (Q96PU5)
E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)
Gene: NEDD4L

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	28972136
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 153 Hs			1 975
+	Hs
		849416 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		NED4L_HUMAN (1-975): 0: 1033: 100.00
+	Hs
		159084 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		159031 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		849444 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		WWP1_HUMAN (1-972): 0: 781: 33.13
+	Hs
		125000 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		1294888 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		849411 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		808052 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		808078 UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		125808 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		125262 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		125335 UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		159070 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		HUWE1_HUMAN (358-973): 3.88e-170: 554: 32.26
+	Hs
		849353 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		HUWE1_HUMAN (358-973): 3.88e-170: 554: 32.26
+	Hs
		919765 UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58		HUWE1_HUMAN (358-973): 3.88e-170: 554: 32.26
+	Hs
		919782 UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58		HACE1_HUMAN (463-968): 7.94e-168: 516: 33.53
+	Hs
		849452 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71
+	Hs
		849451 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		SMUF2_HUMAN (21-324): 2e-29: 127: 22.56
+	Hs
		849351 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		HECW1_HUMAN (144-528): 1.92e-09: 64.2: 13.73
+	Hs
		919762 UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58		HECW1_HUMAN (144-528): 1.92e-09: 64.2: 13.73