HitPredict

Interactor 1: UB2L6 (O14933)
Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L6) (Retinoic acid-induced gene B protein) (RIG-B) (UbcH8) (Ubiquitin carrier protein L6) (Ubiquitin-protein ligase L6)
Gene: UBE2L6

Interactor 2: FBW1A (Q9Y297)
F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)
Gene: BTRC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	37689310
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	UQ_con~WD40
Common GO terms	GO:0000209 - protein polyubiquitination GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 153 Hs			1 605
+	Hs
		849492 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		919912 UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		895959 UB2D3_HUMAN (2-149): 5.99e-74: 219: 36.24		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		895947 UB2D3_HUMAN (2-149): 5.99e-74: 219: 36.24		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		896507 UBE2N_HUMAN (4-151): 4.19e-65: 197: 29.73		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		159067 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		TRAF7_HUMAN (416-589): 7.75e-29: 123: 27.12
+	Dm
		218245 UBCD1_DROME (2-149): 1.11e-74: 221: 37.58		O44382_DROME (466-605): 2.38e-30: 127: 29.37
+	Hs
		1163056 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		TRAF7_HUMAN (416-589): 7.75e-29: 123: 27.12
+	Hs
		849344 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		TRAF7_HUMAN (416-589): 7.75e-29: 123: 27.12
+	Hs
		919755 UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58		TRAF7_HUMAN (416-589): 7.75e-29: 123: 27.12
+	Hs
		932534 UB2L3_HUMAN (1-152): 6.11e-66: 199: 55.26		TRAF7_HUMAN (416-589): 7.75e-29: 123: 27.12
+	Hs
		245581 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		TBL1X_HUMAN (501-605): 3.8e-15: 80.4: 19.13
+	Hs
		849435 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		TBL1R_HUMAN (501-605): 3.85e-15: 80.4: 16.67
+	Hs
		1282344 UB2E3_HUMAN (3-148): 1.55e-68: 207: 31.97		TBL1R_HUMAN (501-605): 3.85e-15: 80.4: 16.67
+	Hs
		245625 UB2E3_HUMAN (3-148): 1.55e-68: 207: 31.97		TBL1X_HUMAN (501-605): 3.8e-15: 80.4: 19.13
+	At
		189083 UBC28_ARATH (2-149): 7e-76: 224: 36.91		GBLPA_ARATH (439-584): 1.06e-09: 62.4: 31.21
+	At
		188984 UBC9_ARATH (2-149): 6.62e-75: 221: 36.24		GBLPA_ARATH (439-584): 1.06e-09: 62.4: 31.21
+	At
		188985 UBC10_ARATH (2-149): 7.23e-75: 221: 36.24		GBLPA_ARATH (439-584): 1.06e-09: 62.4: 31.21
+	At
		188986 UBC11_ARATH (2-149): 5.14e-75: 221: 36.91		GBLPA_ARATH (439-584): 1.06e-09: 62.4: 31.21