HitPredict

Interactor 1: CSKP (O14936)
Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog)
Gene: CASK

Interactor 2: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.641

Property	Details
Experiments	36634849, 35063084, unassigned3713
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation, fluorescence polarization spectroscopy
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 926 Hs			1 758
+	Hs
		497003 MPP2_HUMAN (420-926): 8.18e-154: 466: 39.27		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496940 DLG1_HUMAN (405-923): 2.05e-144: 453: 21.91		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		497224 MARK2_HUMAN (4-680): 5.16e-140: 438: 18.64		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496358 MARK3_HUMAN (4-669): 7.23e-139: 434: 19.62		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		497452 MARK4_HUMAN (4-628): 5.86e-135: 423: 19.53		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Rn
		439487 KCC2B_RAT (8-549): 3.58e-135: 417: 30.56		TAU_RAT (1-758): 4.86e-75: 260: 71.47
+	Rn
		94121 KCC2B_RAT (8-549): 3.58e-135: 417: 30.56		F1LST4_RAT (1-757): 8.59e-75: 260: 71.56
+	Hs
		496977 KCC2D_HUMAN (8-312): 3.56e-88: 291: 47.71		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		92372 E9PBG7_HUMAN (8-312): 1.03e-86: 288: 47.39		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		497824 KCC2A_HUMAN (8-312): 6.34e-85: 282: 46.08		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		503266 MARK3_HUMAN (4-669): 7.23e-139: 434: 19.62		MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55
+	Hs
		654032 MARK4_HUMAN (4-628): 5.86e-135: 423: 19.53		MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56
+	Hs
		503298 MARK4_HUMAN (4-628): 5.86e-135: 423: 19.53		MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55
+	Rn
		506692 KCC2A_RAT (8-312): 5.96e-85: 282: 46.08		TAU_RAT (1-758): 4.86e-75: 260: 71.47
+	Rn
		94129 KCC2A_RAT (8-312): 5.96e-85: 282: 46.08		F1LST4_RAT (1-757): 8.59e-75: 260: 71.56
+	Mm
		581224 DLG4_MOUSE (402-922): 5.68e-145: 449: 22.37		NFH_MOUSE (284-730): 4.84e-16: 84.7: 14.99
+	Mm
		88458 DLG4_MOUSE (402-922): 5.68e-145: 449: 22.37		D3Z656_MOUSE (72-555): 1.33e-11: 70.4: 11.56
+	Mm
		1143433 DLG4_MOUSE (402-922): 5.68e-145: 449: 22.37		SYNJ1_MOUSE (129-637): 3.11e-11: 69.3: 11.20
+	Mm
		592770 KCC2D_MOUSE (8-312): 3.56e-88: 291: 47.71		MTAP2_MOUSE (26-758): 1.71e-30: 131: 23.89
+	Rn
		506773 KCC2A_RAT (8-312): 5.96e-85: 282: 46.08		PCLO_RAT (3-721): 3.96e-10: 65.9: 8.48