HitPredict

Interactor 1: CSKP (O14936)
Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog)
Gene: CASK

Interactor 2: DLG1 (Q12959)
Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg)
Gene: DLG1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.91 1.00 0.958

The method score is based on:

Property Details
Experiments 14960569, 23864692, 10993877, 25852190, 12151521, 32707033
Identification Methods affinity chromatography technology, pull down, fluorescent resonance energy transfer, two hybrid
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Guanylate_kin~Guanylate_kin, Guanylate_kin~PDZ, Guanylate_kin~SH3_1, L27~L27_1, PDZ~PDZ, Guanylate_kin~SH3_2, PDZ~SH3_2, SH3_1~SH3_2
Common GO terms GO:0004385 - guanylate kinase activity
GO:0005604 - basement membrane
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
and 2 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 926
Hs

1 904
+ Mm
+ Rn
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Dm
+ Dm
+ Hs
+ Mm
+ Mm
+ Mm
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024