HitPredict

Interactor 1: CSKP (O14936)
Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog)
Gene: CASK

Interactor 2: SNTB2 (Q13425)
Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin-3) (SNT3) (Syntrophin-like) (SNTL)
Gene: SNTB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.867

Property	Details
Experiments	33961781, 25852190, 32707033
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Guanylate_kin~PDZ, PDZ~PDZ, PH~Pkinase, PDZ~SH3_2
Common GO terms	GO:0005516 - calmodulin binding GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 926 Hs			1 540
+	Hs
		159207 CSKP_HUMAN (1-926): 0: 973: 100.00		SNTB1_HUMAN (24-539): 2.43e-151: 445: 55.30
+	Hs
		159269 CSKP_HUMAN (1-926): 0: 973: 100.00		LIN7B_HUMAN (25-229): 4.57e-39: 143: 28.23
+	Mm
		251089 CSKP_MOUSE (1-926): 0: 973: 99.89		LIN7B_MOUSE (25-229): 7.48e-39: 143: 27.27
+	Hs
		158254 CSKP_HUMAN (1-926): 0: 973: 100.00		LIN7A_HUMAN (82-202): 4.94e-35: 133: 32.23
+	Hs
		159277 CSKP_HUMAN (1-926): 0: 973: 100.00		LIN7C_HUMAN (85-202): 2.22e-35: 133: 34.75
+	Mm
		251090 CSKP_MOUSE (1-926): 0: 973: 99.89		LIN7C_MOUSE (85-202): 2.22e-35: 133: 34.75
+	Mm
		251104 CSKP_MOUSE (1-926): 0: 973: 99.89		DLG1_MOUSE (7-322): 5.28e-28: 120: 17.13
+	Hs
		159200 CSKP_HUMAN (1-926): 0: 973: 100.00		DLG1_HUMAN (2-419): 1.78e-27: 119: 15.51
+	Hs
		159190 CSKP_HUMAN (1-926): 0: 973: 100.00		DLG4_HUMAN (66-394): 4.83e-27: 117: 16.02
+	Hs
		159249 CSKP_HUMAN (1-926): 0: 973: 100.00		DLG3_HUMAN (117-399): 4.14e-22: 102: 15.97
+	Rn
		1144009 CSKP_RAT (1-926): 0: 945: 97.73		DLG1_RAT (3-198): 4.08e-22: 102: 25.34
+	Dm
		1096800 CSKP_DROME (1-926): 0: 835: 60.38		Q9VBY7_DROME (105-202): 3.73e-36: 135: 38.78
+	Ce
		873636 LIN2_CAEEL (2-926): 0: 744: 45.21		Q9U245_CAEEL (106-235): 1.35e-36: 136: 29.23
+	Dm
		116476 M9PJD0_DROME (287-926): 2.45e-154: 500: 24.89		Q9VBY7_DROME (105-202): 3.73e-36: 135: 38.78
+	Hs
		1050415 MPP2_HUMAN (420-926): 8.18e-154: 466: 39.27		LIN7B_HUMAN (25-229): 4.57e-39: 143: 28.23
+	Hs
		1050418 MPP2_HUMAN (420-926): 8.18e-154: 466: 39.27		LIN7C_HUMAN (85-202): 2.22e-35: 133: 34.75
+	Hs
		158282 MPP2_HUMAN (420-926): 8.18e-154: 466: 39.27		LIN7A_HUMAN (82-202): 4.94e-35: 133: 32.23
+	Mm
		1143555 MPP2_MOUSE (347-926): 5.87e-155: 469: 37.48		DLG4_MOUSE (66-394): 4.96e-27: 117: 16.32
+	Hs
		1021489 MPP2_HUMAN (420-926): 8.18e-154: 466: 39.27		DLG1_HUMAN (2-419): 1.78e-27: 119: 15.51
+	Dm
		53136 A1Z8G0_DROME (364-925): 1.05e-151: 462: 28.95		DLG1_DROME (119-219): 8.38e-15: 79.9: 33.96