HitPredict

Interactor 1: ML12B (O14950)
Myosin regulatory light chain 12B (MLC-2A) (MLC-2) (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2) (SHUJUN-1)
Gene: MYL12B

Interactor 2: DAPK1 (P53355)
Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1)
Gene: DAPK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	15616583
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ank_2~EF-hand_7, EF-hand_7~Pkinase
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 172 Hs			1 1430
+	Hs
		159518 ML12B_HUMAN (1-172): 1.42e-67: 204: 100.00		DAPK3_HUMAN (1-376): 1.82e-120: 385: 60.00
+	Hs
		159577 ML12B_HUMAN (1-172): 1.42e-67: 204: 100.00		MYLK_HUMAN (1-319): 4.96e-76: 281: 44.06
+	Gg
		361267 MLRM_CHICK (1-172): 1.14e-65: 199: 92.44		MYLK_CHICK (1-344): 5.69e-77: 284: 41.97
+	At
		989458 CDPK1_ARATH (62-172): 3.22e-14: 71: 20.18		CDPK1_ARATH (4-446): 2.79e-128: 412: 28.73
+	Hs
		624354 MYL9_HUMAN (1-172): 2.61e-66: 201: 93.02		MYLK_HUMAN (1-319): 4.96e-76: 281: 44.06
+	Hs
		580651 ML12A_HUMAN (15-172): 2.3e-65: 199: 99.37		MYLK_HUMAN (1-319): 4.96e-76: 281: 44.06
+	At
		1105900 CDPKB_ARATH (103-172): 1.13e-12: 66.8: 27.14		CDPKB_ARATH (3-446): 6.06e-127: 405: 26.56
+	Gm
		1196117 Q84P28_SOYBN (25-112): 1.15e-10: 61: 18.28		Q84P28_SOYBN (3-446): 6.64e-129: 410: 26.44
+	At
		1104924 CDPK4_ARATH (37-172): 5.35e-13: 67.6: 19.15		CDPK4_ARATH (3-446): 1.12e-125: 402: 26.44
+	At
		989461 CDPK1_ARATH (62-172): 3.22e-14: 71: 20.18		KIN10_ARATH (7-371): 1.63e-120: 388: 30.06
+	At
		483143 CALM4_ARATH (98-171): 7.33e-17: 74.9: 24.32		CIPKO_ARATH (4-414): 7.52e-120: 383: 23.57
+	At
		188340 CML8_ARATH (90-171): 3.04e-12: 62.8: 20.73		CIPKO_ARATH (4-414): 7.52e-120: 383: 23.57
+	At
		976670 CALM6_ARATH (32-93): 7.82e-12: 61.7: 31.82		CIPKO_ARATH (4-414): 7.52e-120: 383: 23.57
+	Hs
		648542 CALL3_HUMAN (32-93): 8.36e-11: 58.6: 25.76		KCC1D_HUMAN (2-325): 9.17e-120: 381: 35.39
+	Hs
		483947 CALM1_HUMAN (20-93): 8.65e-10: 56: 24.36		KCC1D_HUMAN (2-325): 9.17e-120: 381: 35.39
+	Hs
		648500 CALL3_HUMAN (32-93): 8.36e-11: 58.6: 25.76		KCC1A_HUMAN (7-319): 5.17e-118: 376: 38.02
+	Hs
		483928 CALM1_HUMAN (20-93): 8.65e-10: 56: 24.36		KCC2D_HUMAN (2-383): 1.06e-116: 377: 27.94
+	Hs
		484002 CALM2_HUMAN (20-93): 8.65e-10: 56: 24.36		KCC2D_HUMAN (2-383): 1.06e-116: 377: 27.94
+	Hs
		483929 CALM1_HUMAN (20-93): 8.65e-10: 56: 24.36		KCC1A_HUMAN (7-319): 5.17e-118: 376: 38.02
+	Dm
		773033 SQH_DROME (1-172): 2.29e-61: 189: 81.03		Q95SK9_DROME (1-278): 3.62e-69: 241: 43.01