HitPredict

Interactor 1: ML12B (O14950)
Myosin regulatory light chain 12B (MLC-2A) (MLC-2) (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2) (SHUJUN-1)
Gene: MYL12B

Interactor 2: IQCE (Q6IPM2)
IQ domain-containing protein E
Gene: IQCE

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	EF-hand_7~IQ
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 172 Hs			1 695
+	Hs
		1153108 Q9BRL5_HUMAN (102-171): 7.07e-20: 82.5: 27.14		IQCE_HUMAN (1-695): 7.25e-105: 336: 100.00
+	Hs
		72876 B4DJ51_HUMAN (20-93): 8.65e-10: 56: 24.36		IQCE_HUMAN (1-695): 7.25e-105: 336: 100.00
+	Hs
		159549 ML12B_HUMAN (1-172): 1.42e-67: 204: 100.00		MYH9_HUMAN (154-637): 5.07e-18: 91.2: 9.71
+	Hs
		624341 MYL9_HUMAN (1-172): 2.61e-66: 201: 93.02		MYH9_HUMAN (154-637): 5.07e-18: 91.2: 9.71
+	Hs
		159551 ML12B_HUMAN (1-172): 1.42e-67: 204: 100.00		MYH11_HUMAN (25-577): 8.22e-17: 87.3: 12.44
+	Hs
		580614 ML12A_HUMAN (15-172): 2.3e-65: 199: 99.37		MYH9_HUMAN (154-637): 5.07e-18: 91.2: 9.71
+	Hs
		159550 ML12B_HUMAN (1-172): 1.42e-67: 204: 100.00		MYH10_HUMAN (154-652): 2.18e-16: 85.8: 11.48
+	Hs
		624342 MYL9_HUMAN (1-172): 2.61e-66: 201: 93.02		MYH10_HUMAN (154-652): 2.18e-16: 85.8: 11.48
+	Mm
		1143166 Q6ZWQ9_MOUSE (1-172): 7.34e-67: 203: 97.67		MYH10_MOUSE (154-652): 1.13e-15: 83.5: 11.48
+	Hs
		580616 ML12A_HUMAN (15-172): 2.3e-65: 199: 99.37		MYH11_HUMAN (25-577): 8.22e-17: 87.3: 12.44
+	Hs
		580615 ML12A_HUMAN (15-172): 2.3e-65: 199: 99.37		MYH10_HUMAN (154-652): 2.18e-16: 85.8: 11.48
+	Dm
		773034 SQH_DROME (1-172): 2.29e-61: 189: 81.03		MYSN_DROME (167-671): 1.8e-14: 79.6: 13.41
+	Hs
		159595 ML12B_HUMAN (1-172): 1.42e-67: 204: 100.00		MYH14_HUMAN (174-541): 6.22e-09: 61.8: 16.92
+	Hs
		580665 ML12A_HUMAN (15-172): 2.3e-65: 199: 99.37		MYH14_HUMAN (174-541): 6.22e-09: 61.8: 16.92
+	Hs
		501101 MLRV_HUMAN (9-166): 1.98e-54: 171: 57.23		MYH1_HUMAN (87-488): 3.97e-10: 65.7: 10.86
+	Ce
		361111 MLR1_CAEEL (24-170): 2.51e-39: 133: 49.32		MYO4_CAEEL (55-651): 2.45e-10: 66.1: 10.20
+	Ce
		361112 MLR2_CAEEL (24-170): 1.91e-39: 133: 49.32		MYO4_CAEEL (55-651): 2.45e-10: 66.1: 10.20
+	Dm
		404219 MLR_DROME (13-163): 1.86e-29: 109: 42.21		MYSA_DROME (158-652): 2.25e-11: 69.6: 10.42
+	Hs
		648467 CALL3_HUMAN (32-93): 8.36e-11: 58.6: 25.76		MYH9_HUMAN (154-637): 5.07e-18: 91.2: 9.71
+	Ce
		104561 CALM_CAEEL (20-93): 1.03e-09: 56: 26.92		G5EBY3_CAEEL (141-499): 2.05e-11: 69.8: 17.86