HitPredict

Interactor 1: HGS (O14964)
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)
Gene: HGS

Interactor 2: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.746

Property	Details
Experiments	23153581, 25588945, 18508924, 34761192, 35384245, 15212941, 23602387, 23477725, 20308550
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005768 - endosome GO:0007165 - signal transduction GO:0031901 - early endosome membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 777 Hs			1 1210
+	Hs
		276982 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		159886 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		ERBB3_HUMAN (1-1210): 0: 1080: 40.95
+	Hs
		339057 GGA3_HUMAN (6-678): 1.67e-44: 173: 13.14		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		159848 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		RET_HUMAN (420-1058): 5.61e-129: 425: 22.69
+	Hs
		159938 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52
+	Hs
		159900 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76
+	Hs
		160216 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHA6_HUMAN (629-1016): 8.37e-118: 393: 27.80
+	Hs
		160004 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23
+	Hs
		159897 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79
+	Hs
		159843 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87
+	Hs
		159898 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHA3_HUMAN (654-981): 7.78e-111: 372: 34.51
+	Hs
		276988 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		RET_HUMAN (420-1058): 5.61e-129: 425: 22.69
+	Hs
		434297 GGA3_HUMAN (6-678): 1.67e-44: 173: 13.14		RET_HUMAN (420-1058): 5.61e-129: 425: 22.69
+	Hs
		277037 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52
+	Hs
		277152 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		EPHA6_HUMAN (629-1016): 8.37e-118: 393: 27.80
+	Hs
		277067 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23
+	Hs
		277010 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79
+	Hs
		277011 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		EPHA3_HUMAN (654-981): 7.78e-111: 372: 34.51
+	Hs
		159923 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		KSYK_HUMAN (716-961): 1.13e-53: 201: 41.70
+	Hs
		435783 GGA3_HUMAN (6-678): 1.67e-44: 173: 13.14		IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47