HitPredict

Interactor 1: HGS (O14964)
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)
Gene: HGS

Interactor 2: NFL (P07196)
Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) (Neurofilament triplet L protein)
Gene: NEFL

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	26871637
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0019904 - protein domain specific binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 777 Hs			1 543
+	Hs
		159963 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		K22O_HUMAN (69-414): 1.55e-134: 406: 32.09
+	Hs
		422263 FGD4_HUMAN (4-382): 6.5e-48: 184: 13.77		NFL_HUMAN (1-543): 1.42e-151: 446: 100.00
+	Hs
		159852 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		VIME_HUMAN (34-402): 6.74e-84: 270: 49.59
+	Hs
		160204 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		KRT82_HUMAN (32-402): 1.08e-79: 260: 32.17
+	Hs
		159824 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		K2C75_HUMAN (2-411): 2.04e-77: 255: 28.40
+	Hs
		159868 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		GFAP_HUMAN (66-401): 1.36e-70: 234: 48.21
+	Hs
		159920 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		PERI_HUMAN (9-401): 1.77e-69: 232: 48.12
+	Hs
		160121 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		KRT35_HUMAN (2-400): 1.46e-67: 227: 26.43
+	Hs
		159814 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		KRT36_HUMAN (1-456): 2.79e-67: 226: 25.44
+	Hs
		159834 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		K2C6A_HUMAN (56-419): 5.65e-62: 215: 31.06
+	Hs
		111156 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		I6L9F6_HUMAN (219-376): 2.5e-29: 119: 61.01
+	Hs
		957982 FGD1_HUMAN (2-400): 2.19e-36: 149: 14.81		AINX_HUMAN (66-401): 1.66e-91: 290: 58.11
+	Hs
		241144 TOM1_HUMAN (5-428): 1.81e-54: 197: 18.16		GFAP_HUMAN (66-401): 1.36e-70: 234: 48.21
+	Hs
		159796 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		KRT86_HUMAN (238-543): 3.82e-09: 61.1: 13.29
+	Hs
		1081765 ANFY1_HUMAN (156-219): 2.38e-14: 79.3: 50.00		AINX_HUMAN (66-401): 1.66e-91: 290: 58.11
+	Hs
		3229 A0A0S2Z4Q4_HUMAN (1-703): 3.76e-49: 186: 40.68		I6L9F6_HUMAN (219-376): 2.5e-29: 119: 61.01