HitPredict

Interactor 1: HGS (O14964)
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)
Gene: HGS

Interactor 2: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005769 - early endosome GO:0007165 - signal transduction GO:0010628 - positive regulation of gene expression
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 777 Hs			1 1114
+	Hs
		276988 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		RET_HUMAN (1-1114): 0: 1295: 100.00
+	Hs
		159885 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11
+	Hs
		159864 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61
+	Hs
		159889 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		FGFR3_HUMAN (501-1061): 4.63e-147: 462: 33.16
+	Hs
		159830 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24
+	Hs
		159837 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69
+	Hs
		160015 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		NTRK2_HUMAN (590-1018): 1.26e-124: 403: 30.74
+	Hs
		159888 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		FGFR4_HUMAN (535-1054): 4.33e-124: 401: 37.89
+	Rn
		1144355 HGS_RAT (1-777): 3.19e-100: 328: 93.44		NTRK2_RAT (636-1018): 2.33e-122: 397: 32.17
+	Mm
		546322 HGS_MOUSE (1-777): 2.55e-98: 323: 93.31		NTRK2_MOUSE (622-1018): 1.6e-122: 397: 31.33
+	Hs
		160014 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		NTRK3_HUMAN (638-1020): 2.11e-106: 355: 31.19
+	Hs
		277002 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11
+	Hs
		276996 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61
+	Hs
		277004 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		FGFR3_HUMAN (501-1061): 4.63e-147: 462: 33.16
+	Hs
		276982 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24
+	Hs
		241132 TOM1_HUMAN (5-428): 1.81e-54: 197: 18.16		NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69
+	Hs
		276985 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69
+	Hs
		159845 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		CSF1R_HUMAN (706-1018): 4.91e-74: 267: 40.22
+	Hs
		277003 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		FGFR4_HUMAN (535-1054): 4.33e-124: 401: 37.89
+	Hs
		277073 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		NTRK3_HUMAN (638-1020): 2.11e-106: 355: 31.19