HitPredict

Interactor 1: HGS (O14964)
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)
Gene: HGS

Interactor 2: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.987

Property	Details
Experiments	16771824, 23314748, 20504764, 16735510, 16429130, 26456826, 28190767, 28581508, 31699778, 18626516, 38803224, 11988743, 11916981, 12207904, 12750381, 12230472
Identification Methods	affinity chromatography technology, pull down, x-ray crystallography, two hybrid, nuclear magnetic resonance, circular dichroism, surface plasmon resonance
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	VHS~ubiquitin
Common GO terms	GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 777 Hs			1 685
+	Hs
		241137 TOM1_HUMAN (5-428): 1.81e-54: 197: 18.16		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		276993 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475949 TM1L2_HUMAN (5-448): 6.41e-50: 185: 17.17		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476481 GGA3_HUMAN (6-678): 1.67e-44: 173: 13.14		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476138 STAM1_HUMAN (4-172): 1.45e-42: 164: 28.40		UBC_HUMAN (1-685): 0: 846: 100.00
+	Dm
		477530 HRS_DROME (6-672): 1.2e-54: 203: 35.98		UBIQP_DROME (1-610): 0: 752: 99.84
+	Ce
		477552 Q17796_CAEEL (5-737): 9.07e-93: 307: 33.11		UBIQ1_CAEEL (1-229): 5.97e-87: 292: 98.25
+	Sc
		477314 VPS27_YEAST (3-650): 4.65e-44: 170: 18.35		UBI4P_YEAST (381-685): 5e-122: 370: 95.74
+	Rn
		1144280 HGS_RAT (1-777): 3.19e-100: 328: 93.44		UBC_RAT (1-108): 1.27e-29: 127: 90.74
+	Mm
		476969 HGS_MOUSE (1-777): 2.55e-98: 323: 93.31		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Hs
		277047 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00
+	Mm
		292343 STAM2_MOUSE (4-520): 1.53e-52: 192: 15.28		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Mm
		292209 TOM1_MOUSE (5-440): 1.44e-51: 189: 17.71		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Hs
		241134 TOM1_HUMAN (5-428): 1.81e-54: 197: 18.16		ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69
+	Mm
		476811 TM1L2_MOUSE (5-448): 1.16e-45: 173: 16.77		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Hs
		276992 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70
+	Rn
		78185 B5DF55_RAT (4-158): 5.5e-43: 166: 31.61		UBC_RAT (1-108): 1.27e-29: 127: 90.74
+	Mm
		69089 A8Y5G5_MOUSE (141-480): 2.06e-41: 165: 19.26		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Mm
		476756 STAM1_MOUSE (4-158): 1.81e-42: 164: 31.61		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Hs
		475215 GGA3_HUMAN (6-678): 1.67e-44: 173: 13.14		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70