HitPredict

Interactor 1: HGS (O14964)
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)
Gene: HGS

Interactor 2: EPHA3 (P29320)
Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1)
Gene: EPHA3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005769 - early endosome GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 777 Hs			1 983
+	Hs
		159937 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHA5_HUMAN (7-983): 0: 1202: 65.97
+	Hs
		160004 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHA7_HUMAN (6-979): 0: 1198: 61.46
+	Hs
		159900 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHB2_HUMAN (29-981): 0: 1167: 55.90
+	Hs
		159938 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHA4_HUMAN (8-983): 0: 1164: 62.40
+	Hs
		160216 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHA6_HUMAN (3-980): 0: 1146: 60.16
+	Hs
		277011 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		EPHA3_HUMAN (1-983): 0: 1248: 100.00
+	Hs
		159899 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHA8_HUMAN (29-982): 0: 1099: 56.57
+	Hs
		665436 GGA3_HUMAN (6-678): 1.67e-44: 173: 13.14		EPHA3_HUMAN (1-983): 0: 1248: 100.00
+	Hs
		159897 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHA2_HUMAN (27-983): 0: 1061: 50.47
+	Hs
		277036 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		EPHA5_HUMAN (7-983): 0: 1202: 65.97
+	Hs
		277067 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		EPHA7_HUMAN (6-979): 0: 1198: 61.46
+	Hs
		872497 GGA3_HUMAN (6-678): 1.67e-44: 173: 13.14		EPHA5_HUMAN (7-983): 0: 1202: 65.97
+	Hs
		277037 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		EPHA4_HUMAN (8-983): 0: 1164: 62.40
+	Hs
		277152 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		EPHA6_HUMAN (3-980): 0: 1146: 60.16
+	Hs
		277012 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		EPHA8_HUMAN (29-982): 0: 1099: 56.57
+	Hs
		665508 STAM1_HUMAN (4-172): 1.45e-42: 164: 28.40		EPHA8_HUMAN (29-982): 0: 1099: 56.57
+	Hs
		277010 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		EPHA2_HUMAN (27-983): 0: 1061: 50.47
+	Hs
		665303 STAM1_HUMAN (4-172): 1.45e-42: 164: 28.40		EPHA2_HUMAN (27-983): 0: 1061: 50.47
+	Hs
		159843 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		INSR_HUMAN (375-880): 6.57e-136: 444: 30.32
+	Hs
		435783 GGA3_HUMAN (6-678): 1.67e-44: 173: 13.14		IGF1R_HUMAN (366-883): 1.6e-139: 453: 30.02