HitPredict

Interactor 1: HGS (O14964)
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)
Gene: HGS

Interactor 2: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.74 0.60 0.667

The method score is based on:

Property Details
Experiments 25588945, 12230472, 23602387
Identification Methods affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, ubiquitination reaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005829 - cytosol
GO:0006622 - protein targeting to lysosome
GO:0019904 - protein domain specific binding
GO:0030948 - negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031623 - receptor internalization
and 2 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 777
Hs

1 1319
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024