HitPredict

Interactor 1: HGS (O14964)
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)
Gene: HGS

Interactor 2: SNX1 (Q13596)
Sorting nexin-1
Gene: SNX1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	11110793, 19874558
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005764 - lysosome GO:0005768 - endosome GO:0005829 - cytosol GO:0031623 - receptor internalization GO:0031901 - early endosome membrane and 1 others more... GO:0035091 - phosphatidylinositol binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 777 Hs			1 522
+	Hs
		160232 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		SNX7_HUMAN (114-515): 3.23e-86: 273: 19.65
+	Hs
		1040498 STAM1_HUMAN (4-172): 1.45e-42: 164: 28.40		SNX1_HUMAN (1-522): 8.2e-149: 438: 100.00
+	Hs
		160244 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		SNX5_HUMAN (142-520): 9.13e-75: 243: 21.45
+	Hs
		240450 ANFY1_HUMAN (156-219): 2.38e-14: 79.3: 50.00		SNX2_HUMAN (10-522): 3.61e-127: 382: 58.95
+	Hs
		241210 TOM1_HUMAN (5-428): 1.81e-54: 197: 18.16		SNX5_HUMAN (142-520): 9.13e-75: 243: 21.45
+	Hs
		1350530 ANFY1_HUMAN (156-219): 2.38e-14: 79.3: 50.00		SNX9_HUMAN (2-518): 1.33e-93: 298: 14.58
+	Hs
		1350531 ANFY1_HUMAN (156-219): 2.38e-14: 79.3: 50.00		SNX5_HUMAN (142-520): 9.13e-75: 243: 21.45
+	Hs
		1350526 ANFY1_HUMAN (156-219): 2.38e-14: 79.3: 50.00		SNX6_HUMAN (145-520): 1.81e-73: 240: 20.46
+	Hs
		235004 ANFY1_HUMAN (156-219): 2.38e-14: 79.3: 50.00		SNX3_HUMAN (118-273): 6.27e-46: 160: 24.36