HitPredict

Interactor 1: HGS (O14964)
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)
Gene: HGS

Interactor 2: SMAD1 (Q15797)
Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)
Gene: SMAD1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	11094085
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction GO:0008285 - negative regulation of cell population proliferation GO:0010628 - positive regulation of gene expression GO:0046872 - metal ion binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 777 Hs			1 465
+	Hs
		160166 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		SMAD5_HUMAN (2-465): 0: 619: 89.46
+	Hs
		159959 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		SMAD3_HUMAN (3-465): 0: 556: 59.66
+	Hs
		160010 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		SMAD2_HUMAN (3-465): 0: 541: 55.14
+	Mm
		936613 ZFY16_MOUSE (126-499): 1.21e-35: 148: 16.70		SMAD1_MOUSE (1-465): 0: 656: 99.14
+	Hs
		159987 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		SMAD4_HUMAN (13-454): 1.6e-150: 441: 34.28
+	Hs
		313526 ZFYV9_HUMAN (155-489): 1.2e-38: 157: 20.63		SMAD3_HUMAN (3-465): 0: 556: 59.66
+	Hs
		313541 ZFYV9_HUMAN (155-489): 1.2e-38: 157: 20.63		SMAD2_HUMAN (3-465): 0: 541: 55.14
+	Hs
		1035486 ZFY16_HUMAN (137-497): 7.73e-39: 158: 17.76		SMAD4_HUMAN (13-454): 1.6e-150: 441: 34.28
+	Hs
		313534 ZFYV9_HUMAN (155-489): 1.2e-38: 157: 20.63		SMAD4_HUMAN (13-454): 1.6e-150: 441: 34.28