HitPredict

Interactor 1: AURKA (O14965)
Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A)
Gene: AURKA

Interactor 2: TACC1 (O75410)
Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1)
Gene: TACC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.653

Property	Details
Experiments	15064709, 14603251, 14602875
Identification Methods	affinity chromatography technology, two hybrid, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005813 - centrosome GO:0005829 - cytosol GO:0007052 - mitotic spindle organization GO:0030496 - midbody and 1 others more... GO:0051301 - cell division
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 403 Hs			1 805
+	Hs
		264082 AURKB_HUMAN (126-395): 6.86e-131: 381: 71.43		TACC1_HUMAN (1-805): 1.32e-103: 339: 100.00
+	Hs
		160785 AURKA_HUMAN (1-403): 2.51e-162: 463: 100.00		UBP42_HUMAN (44-498): 6e-43: 171: 11.65
+	Hs
		160881 AURKA_HUMAN (1-403): 2.51e-162: 463: 100.00		TACC3_HUMAN (35-803): 1.31e-42: 168: 22.72
+	Dm
		1196975 Q9VGF9_DROME (3-388): 1.83e-132: 387: 46.77		Q86BB4_DROME (568-803): 1.32e-64: 217: 25.73
+	Hs
		311841 AURKC_HUMAN (115-389): 7.45e-130: 377: 68.73		TACC2_HUMAN (7-804): 1.65e-49: 192: 26.54
+	Hs
		160565 AURKA_HUMAN (1-403): 2.51e-162: 463: 100.00		MDC1_HUMAN (24-492): 1.65e-09: 63.9: 13.03
+	Hs
		1186099 AKT3_HUMAN (29-401): 1.27e-140: 411: 23.76		MICA3_HUMAN (49-673): 8.99e-09: 61.5: 10.72
+	Hs
		1056933 AURKB_HUMAN (126-395): 6.86e-131: 381: 71.43		MDC1_HUMAN (24-492): 1.65e-09: 63.9: 13.03