HitPredict

Interactor 1: AURKA (O14965)
Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A)
Gene: AURKA

Interactor 2: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	28205554, 36424410
Identification Methods	fluorescent resonance energy transfer, proximity labelling technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0043066 - negative regulation of apoptotic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 403 Hs			1 454
+	Hs
		346044 AKT1_HUMAN (27-401): 3.06e-138: 404: 25.07		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		347580 AURKB_HUMAN (126-395): 6.86e-131: 381: 71.43		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		160320 AURKA_HUMAN (1-403): 2.51e-162: 463: 100.00		MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40
+	Hs
		160351 AURKA_HUMAN (1-403): 2.51e-162: 463: 100.00		MYCL_HUMAN (29-449): 4.2e-42: 154: 30.11
+	Hs
		160534 AURKA_HUMAN (1-403): 2.51e-162: 463: 100.00		SRBP2_HUMAN (124-446): 8.64e-35: 139: 12.54
+	Hs
		379721 AURKB_HUMAN (126-395): 6.86e-131: 381: 71.43		MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40
+	At
		1105320 KIN10_ARATH (132-400): 5.34e-140: 410: 33.21		MYC2_ARATH (200-454): 1.78e-32: 132: 18.05
+	Hs
		681801 AKT1_HUMAN (27-401): 3.06e-138: 404: 25.07		MAD1_HUMAN (320-453): 2.08e-29: 116: 19.40