HitPredict

Interactor 1: AURKA (O14965)
Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A)
Gene: AURKA

Interactor 2: PP6R3 (Q5H9R7)
Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL)
Gene: PPP6R3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.750

Property	Details
Experiments	24255178, 26186194, 28514442, 33961781, 32989298, 32707033, 36736316, 23443559
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 403 Hs			1 873
+	Hs
		1126024 AURKB_HUMAN (126-395): 6.86e-131: 381: 71.43		PP6R3_HUMAN (1-873): 0: 854: 100.00
+	Hs
		160281 AURKA_HUMAN (1-403): 2.51e-162: 463: 100.00		PP6R2_HUMAN (1-870): 0: 766: 45.79
+	Ce
		70232 G5EDL3_CAEEL (118-383): 2.17e-100: 303: 55.22		PPH6R_CAEEL (1-771): 1.5e-122: 390: 18.43
+	Hs
		969116 KPCE_HUMAN (4-401): 3.82e-137: 410: 24.33		OGFR_HUMAN (689-871): 2.31e-16: 85.7: 17.94