HitPredict

Interactor 1: AURKA (O14965)
Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A)
Gene: AURKA

Interactor 2: CE192 (Q8TEP8)
Centrosomal protein of 192 kDa (Cep192) (Cep192/SPD-2)
Gene: CEP192

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	35709258, 28514442, 20360068, 32707033, 33961781
Identification Methods	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification, pull down
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005813 - centrosome GO:0005814 - centriole GO:0005829 - cytosol GO:0019901 - protein kinase binding GO:0071539 - protein localization to centrosome
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 403 Hs			1 2537
+	Hs
		129030 PLK4_HUMAN (130-391): 1.82e-53: 192: 37.74		CE192_HUMAN (1-2537): 0: 4785: 100.00
+	Mm
		93523 PLK4_MOUSE (130-391): 2.11e-52: 189: 36.60		E9Q4Y4_MOUSE (1-2537): 0: 4476: 64.54
+	Hs
		160788 AURKA_HUMAN (1-403): 2.51e-162: 463: 100.00		Q9HCK3_HUMAN (1419-2537): 0: 2297: 99.82
+	Hs
		1292236 AURKB_HUMAN (126-395): 6.86e-131: 381: 71.43		Q9HCK3_HUMAN (1419-2537): 0: 2297: 99.82
+	Hs
		129054 PLK4_HUMAN (130-391): 1.82e-53: 192: 37.74		Q9HCK3_HUMAN (1419-2537): 0: 2297: 99.82