HitPredict

Interactor 1: AURKA (O14965)
Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A)
Gene: AURKA

Interactor 2: CACO1 (Q9P1Z2)
Calcium-binding and coiled-coil domain-containing protein 1 (Calphoglin) (Coiled-coil coactivator protein) (Sarcoma antigen NY-SAR-3)
Gene: CALCOCO1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.718

Property	Details
Experiments	26186194, 28514442, 33961781, 32989298, 32707033
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 403 Hs			1 691
+	Hs
		1201872 AURKB_HUMAN (126-395): 6.86e-131: 381: 71.43		TAXB1_HUMAN (15-680): 1.63e-57: 210: 24.60
+	Mm
		554927 KPCE_MOUSE (4-401): 1.29e-136: 409: 24.57		MYH7_MOUSE (208-683): 3.33e-21: 101: 11.73
+	Hs
		610795 KAPCB_HUMAN (117-400): 2.4e-135: 393: 30.80		MYH2_HUMAN (39-667): 2.8e-26: 117: 9.88
+	Hs
		724784 KPCE_HUMAN (4-401): 3.82e-137: 410: 24.33		MYH9_HUMAN (201-686): 9.8e-21: 100: 12.25
+	Mm
		554901 KPCE_MOUSE (4-401): 1.29e-136: 409: 24.57		MYH6_MOUSE (208-683): 1.01e-20: 99.7: 10.70
+	Hs
		681696 AKT1_HUMAN (27-401): 3.06e-138: 404: 25.07		MYH9_HUMAN (201-686): 9.8e-21: 100: 12.25
+	Hs
		568568 KAPCA_HUMAN (117-400): 5.82e-136: 394: 29.76		MYH10_HUMAN (19-516): 9.32e-23: 106: 11.80
+	Hs
		568567 KAPCA_HUMAN (117-400): 5.82e-136: 394: 29.76		MYH9_HUMAN (201-686): 9.8e-21: 100: 12.25
+	Hs
		522538 KAPCB_HUMAN (117-400): 2.4e-135: 393: 30.80		MYH1_HUMAN (187-684): 1.71e-20: 99.3: 10.62
+	Hs
		610802 KAPCB_HUMAN (117-400): 2.4e-135: 393: 30.80		MYH4_HUMAN (208-691): 2.16e-19: 95.5: 10.53
+	Hs
		725220 AURKB_HUMAN (126-395): 6.86e-131: 381: 71.43		MYH10_HUMAN (19-516): 9.32e-23: 106: 11.80
+	Hs
		724962 AURKB_HUMAN (126-395): 6.86e-131: 381: 71.43		MYH9_HUMAN (201-686): 9.8e-21: 100: 12.25
+	Hs
		522653 AURKC_HUMAN (115-389): 7.45e-130: 377: 68.73		MYH7_HUMAN (208-683): 6.52e-22: 103: 11.52
+	Hs
		528433 AURKC_HUMAN (115-389): 7.45e-130: 377: 68.73		MYH8_HUMAN (208-687): 2.95e-21: 101: 10.70
+	Hs
		728503 AURKB_HUMAN (126-395): 6.86e-131: 381: 71.43		MYH11_HUMAN (278-689): 1.17e-19: 96.6: 12.47
+	Hs
		522582 AURKC_HUMAN (115-389): 7.45e-130: 377: 68.73		MYH1_HUMAN (187-684): 1.71e-20: 99.3: 10.62
+	Hs
		728527 AURKC_HUMAN (115-389): 7.45e-130: 377: 68.73		MYH11_HUMAN (278-689): 1.17e-19: 96.6: 12.47
+	Hs
		1357872 AURKC_HUMAN (115-389): 7.45e-130: 377: 68.73		MYH4_HUMAN (208-691): 2.16e-19: 95.5: 10.53
+	Hs
		528359 KAPCB_HUMAN (117-400): 2.4e-135: 393: 30.80		MYH6_HUMAN (306-685): 2.17e-14: 79.3: 10.97
+	Hs
		568645 KAPCA_HUMAN (117-400): 5.82e-136: 394: 29.76		CACO2_HUMAN (260-475): 1.2e-10: 66: 16.67