HitPredict

Interactor 1: MYPT1 (O14974)
Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit)
Gene: PPP1R12A

Interactor 2: NUAK1 (O60285)
NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1)
Gene: NUAK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	32707033, 24785407
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~Pkinase
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0030155 - regulation of cell adhesion GO:0035507 - regulation of myosin-light-chain-phosphatase activity
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1030 Hs			1 661
+	Hs
		161449 MYPT1_HUMAN (1-1030): 4.91e-140: 448: 100.00		NUAK2_HUMAN (1-661): 2.59e-148: 445: 49.92
+	Hs
		229975 PP12C_HUMAN (538-1030): 4.93e-33: 139: 20.35		NUAK1_HUMAN (1-661): 0: 581: 100.00
+	Hs
		225111 MYPT2_HUMAN (1-905): 6.08e-21: 101: 11.37		NUAK1_HUMAN (1-661): 0: 581: 100.00
+	Hs
		647851 DAPK1_HUMAN (43-515): 3.48e-54: 208: 15.55		MARK3_HUMAN (4-658): 1.17e-156: 471: 27.09
+	Hs
		862065 DAPK1_HUMAN (43-515): 3.48e-54: 208: 15.55		MARK2_HUMAN (1-658): 9.28e-152: 460: 23.88
+	Hs
		862115 DAPK1_HUMAN (43-515): 3.48e-54: 208: 15.55		MARK1_HUMAN (4-658): 1.87e-140: 431: 24.32
+	Hs
		1318219 PP12C_HUMAN (538-1030): 4.93e-33: 139: 20.35		NUAK2_HUMAN (1-661): 2.59e-148: 445: 49.92