HitPredict

Interactor 1: MYPT1 (O14974)
Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit)
Gene: PPP1R12A

Interactor 2: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	15545284
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Ank_2~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1030 Hs			1 193
+	Hs
		161342 MYPT1_HUMAN (1-1030): 4.91e-140: 448: 100.00		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		900403 NOTC2_HUMAN (8-636): 7.56e-77: 279: 18.38		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		925219 NOTC2_HUMAN (8-636): 7.56e-77: 279: 18.38		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		436267 NOTC2_HUMAN (8-636): 7.56e-77: 279: 18.38		RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71
+	Hs
		950942 NOTC2_HUMAN (8-636): 7.56e-77: 279: 18.38		RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40
+	Hs
		893926 NOTC2_HUMAN (8-636): 7.56e-77: 279: 18.38		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		545337 NOTC2_HUMAN (8-636): 7.56e-77: 279: 18.38		RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61
+	Hs
		892331 NOTC2_HUMAN (8-636): 7.56e-77: 279: 18.38		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Hs
		915624 NOTC2_HUMAN (8-636): 7.56e-77: 279: 18.38		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Hs
		883465 RIPK4_HUMAN (1-326): 1.53e-70: 253: 20.06		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		120402 NOTC2_HUMAN (8-636): 7.56e-77: 279: 18.38		RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98
+	Hs
		900896 Q9H4D1_HUMAN (1-326): 3.17e-70: 251: 20.06		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Mm
		892714 ANS1B_MOUSE (44-836): 6.65e-73: 265: 15.88		RAC3_MOUSE (1-179): 4.85e-74: 223: 57.54
+	Hs
		901042 KDIS_HUMAN (1-162): 1.37e-32: 139: 19.10		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		436568 KDIS_HUMAN (1-162): 1.37e-32: 139: 19.10		RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71
+	Hs
		894580 KDIS_HUMAN (1-162): 1.37e-32: 139: 19.10		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		545696 KDIS_HUMAN (1-162): 1.37e-32: 139: 19.10		RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61
+	Hs
		892676 KDIS_HUMAN (1-162): 1.37e-32: 139: 19.10		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Hs
		916068 KDIS_HUMAN (1-162): 1.37e-32: 139: 19.10		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Hs
		120709 KDIS_HUMAN (1-162): 1.37e-32: 139: 19.10		RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98