HitPredict

Interactor 1: MYPT1 (O14974)
Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit)
Gene: PPP1R12A

Interactor 2: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	36931259, 18094049
Identification Methods	proximity labelling technology, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0007165 - signal transduction and 1 others more... GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1030 Hs			1 245
+	Hs
		161349 MYPT1_HUMAN (1-1030): 4.91e-140: 448: 100.00		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		161309 MYPT1_HUMAN (1-1030): 4.91e-140: 448: 100.00		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		161312 MYPT1_HUMAN (1-1030): 4.91e-140: 448: 100.00		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		161346 MYPT1_HUMAN (1-1030): 4.91e-140: 448: 100.00		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		161359 MYPT1_HUMAN (1-1030): 4.91e-140: 448: 100.00		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49
+	Hs
		161313 MYPT1_HUMAN (1-1030): 4.91e-140: 448: 100.00		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97
+	Hs
		883471 RIPK4_HUMAN (1-326): 1.53e-70: 253: 20.06		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		883468 RIPK4_HUMAN (1-326): 1.53e-70: 253: 20.06		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		646759 RIPK4_HUMAN (1-326): 1.53e-70: 253: 20.06		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		647273 Q9H4D1_HUMAN (1-326): 3.17e-70: 251: 20.06		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		683234 RIPK4_HUMAN (1-326): 1.53e-70: 253: 20.06		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		683652 Q96T11_HUMAN (1-326): 6.74e-70: 251: 20.06		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		683708 Q9H4D1_HUMAN (1-326): 3.17e-70: 251: 20.06		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		904467 NOTC2_HUMAN (8-636): 7.56e-77: 279: 18.38		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		980360 NOTC2_HUMAN (8-636): 7.56e-77: 279: 18.38		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49
+	Hs
		883467 RIPK4_HUMAN (1-326): 1.53e-70: 253: 20.06		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		883491 RIPK4_HUMAN (1-326): 1.53e-70: 253: 20.06		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49
+	Hs
		905022 Q96T11_HUMAN (1-326): 6.74e-70: 251: 20.06		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		905108 Q9H4D1_HUMAN (1-326): 3.17e-70: 251: 20.06		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		982413 Q96T11_HUMAN (1-326): 6.74e-70: 251: 20.06		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49