HitPredict

Interactor 1: XPO1 (O14980)
Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog)
Gene: XPO1

Interactor 2: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	26673895
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1071 Hs			1 1239
+	Hs
		163447 XPO1_HUMAN (1-1071): 0: 1022: 100.00		TNIK_HUMAN (1-1239): 0: 1101: 60.56
+	Xl
		1150217 Q6NS03_XENLA (1-1071): 0: 1007: 97.01		Q6DDZ8_XENLA (1-1239): 0: 1097: 59.58
+	Mm
		949411 XPO7_MOUSE (23-1013): 5.43e-120: 397: 13.01		TNIK_MOUSE (1-1239): 0: 1120: 62.43
+	Hs
		163163 XPO1_HUMAN (1-1071): 0: 1022: 100.00		NEK1_HUMAN (23-917): 5.54e-125: 418: 17.52
+	Hs
		148140 XPO1_HUMAN (1-1071): 0: 1022: 100.00		CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33
+	Hs
		162694 XPO1_HUMAN (1-1071): 0: 1022: 100.00		STK3_HUMAN (4-499): 3.17e-119: 381: 30.60
+	Hs
		162687 XPO1_HUMAN (1-1071): 0: 1022: 100.00		STK4_HUMAN (4-517): 8.55e-119: 379: 31.92
+	Hs
		1273247 TNPO1_HUMAN (33-1045): 1.81e-132: 425: 13.84		SIK3_HUMAN (7-915): 2.5e-127: 426: 15.13
+	Hs
		148133 TNPO2_HUMAN (33-1045): 7.78e-129: 415: 14.41		CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33
+	Hs
		148167 XPOT_HUMAN (29-1023): 3.55e-126: 410: 14.85		CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33
+	Mm
		1141482 XPOT_MOUSE (29-1023): 6.32e-125: 407: 14.83		AKT2_MOUSE (2-354): 5.61e-123: 390: 21.43
+	Hs
		149308 XPO5_HUMAN (26-665): 5.8e-100: 344: 16.12		CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33
+	Hs
		148828 IMB1_HUMAN (27-908): 2.89e-90: 311: 11.32		CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33
+	Hs
		1023042 IMB1_HUMAN (27-908): 2.89e-90: 311: 11.32		STK4_HUMAN (4-517): 8.55e-119: 379: 31.92
+	Hs
		1023095 XPO6_HUMAN (20-380): 2.55e-64: 239: 16.71		STK4_HUMAN (4-517): 8.55e-119: 379: 31.92