HitPredict

Interactor 1: XPO1 (O14980)
Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog)
Gene: XPO1

Interactor 2: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	35384245, 23956138
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0016020 - membrane GO:0031965 - nuclear membrane GO:0032991 - protein-containing complex
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1071 Hs			1 1210
+	Hs
		162768 XPO1_HUMAN (1-1071): 0: 1022: 100.00		ERBB4_HUMAN (1-1199): 0: 1137: 49.46
+	Hs
		162330 XPO1_HUMAN (1-1071): 0: 1022: 100.00		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		297142 IPO13_HUMAN (17-1029): 3.79e-133: 429: 16.03		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		338800 TNPO1_HUMAN (33-1045): 1.81e-132: 425: 13.84		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		155507 TNPO2_HUMAN (33-1045): 7.78e-129: 415: 14.41		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		207868 XPOT_HUMAN (29-1023): 3.55e-126: 410: 14.85		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		339101 XPO7_HUMAN (23-1013): 1.48e-120: 398: 13.18		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		339000 XPO5_HUMAN (26-665): 5.8e-100: 344: 16.12		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		338445 IMB1_HUMAN (27-908): 2.89e-90: 311: 11.32		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		339200 TNPO3_HUMAN (24-901): 9.93e-89: 307: 14.37		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		383912 TNPO1_HUMAN (33-1045): 1.81e-132: 425: 13.84		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		338865 XPO6_HUMAN (20-380): 2.55e-64: 239: 16.71		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		383812 IMB1_HUMAN (27-908): 2.89e-90: 311: 11.32		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		162344 XPO1_HUMAN (1-1071): 0: 1022: 100.00		IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47
+	Mm
		1322252 XPO7_MOUSE (23-1013): 5.43e-120: 397: 13.01		FAK2_MOUSE (716-974): 4.22e-52: 201: 37.64
+	Hs
		435716 TNPO1_HUMAN (33-1045): 1.81e-132: 425: 13.84		IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47
+	Hs
		435766 XPO5_HUMAN (26-665): 5.8e-100: 344: 16.12		IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47