HitPredict

Interactor 1: XPO1 (O14980)
Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog)
Gene: XPO1

Interactor 2: RANG (P43487)
Ran-specific GTPase-activating protein (Ran-binding protein 1) (RanBP1)
Gene: RANBP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.825

Property	Details
Experiments	10601307, 10779340, 22833565
Identification Methods	pull down, unspecified method
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	CRM1_C~Ran_BP1
Common GO terms	GO:0005634 - nucleus GO:0005635 - nuclear envelope GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031267 - small GTPase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1071 Hs			1 201
+	Hs
		152753 XPO1_HUMAN (1-1071): 0: 1022: 100.00		RGPD8_HUMAN (1-201): 9.54e-47: 166: 34.31
+	Hs
		63864 XPO1_HUMAN (1-1071): 0: 1022: 100.00		RGPD3_HUMAN (1-201): 2.17e-46: 165: 34.80
+	Hs
		162518 XPO1_HUMAN (1-1071): 0: 1022: 100.00		RBP2_HUMAN (4-164): 1.49e-44: 160: 47.83
+	Hs
		163286 XPO1_HUMAN (1-1071): 0: 1022: 100.00		RANB3_HUMAN (10-186): 4.16e-30: 117: 16.75
+	Hs
		163451 XPO1_HUMAN (1-1071): 0: 1022: 100.00		NUP50_HUMAN (7-161): 5.41e-27: 108: 21.02
+	Sc
		676138 XPO1_YEAST (14-1067): 0: 848: 46.08		YRB1_YEAST (3-165): 2.48e-40: 137: 50.31
+	Sc
		676121 XPO1_YEAST (14-1067): 0: 848: 46.08		YRB2_YEAST (2-155): 4.17e-27: 106: 23.23
+	Hs
		297160 IPO13_HUMAN (17-1029): 3.79e-133: 429: 16.03		RANG_HUMAN (1-201): 7.64e-63: 195: 100.00
+	Hs
		796783 TNPO1_HUMAN (33-1045): 1.81e-132: 425: 13.84		RANG_HUMAN (1-201): 7.64e-63: 195: 100.00
+	Hs
		155547 TNPO2_HUMAN (33-1045): 7.78e-129: 415: 14.41		RANG_HUMAN (1-201): 7.64e-63: 195: 100.00
+	Hs
		796812 XPO7_HUMAN (23-1013): 1.48e-120: 398: 13.18		RANG_HUMAN (1-201): 7.64e-63: 195: 100.00
+	Hs
		1273208 TNPO1_HUMAN (33-1045): 1.81e-132: 425: 13.84		RGPD5_HUMAN (1-201): 9.73e-47: 166: 34.31
+	Hs
		834809 TNPO1_HUMAN (33-1045): 1.81e-132: 425: 13.84		RBP2_HUMAN (4-164): 1.49e-44: 160: 47.83
+	Mm
		1322246 XPO7_MOUSE (23-1013): 5.43e-120: 397: 13.01		RBP2_MOUSE (2-160): 2.69e-45: 161: 49.38
+	Hs
		297205 IPO13_HUMAN (17-1029): 3.79e-133: 429: 16.03		NUP50_HUMAN (7-161): 5.41e-27: 108: 21.02
+	Hs
		1273239 TNPO1_HUMAN (33-1045): 1.81e-132: 425: 13.84		NUP50_HUMAN (7-161): 5.41e-27: 108: 21.02
+	Xl
		1137361 Q5U4V0_XENLA (33-1045): 8.68e-130: 418: 13.75		Q6DCU3_XENLA (37-160): 2.07e-24: 100: 23.81
+	Hs
		483396 IMB1_HUMAN (27-908): 2.89e-90: 311: 11.32		RGPD1_HUMAN (1-201): 7.66e-48: 169: 34.80
+	Hs
		152779 IMB1_HUMAN (27-908): 2.89e-90: 311: 11.32		RGPD8_HUMAN (1-201): 9.54e-47: 166: 34.31
+	Hs
		1334950 XPO5_HUMAN (26-665): 5.8e-100: 344: 16.12		NUP50_HUMAN (7-161): 5.41e-27: 108: 21.02