HitPredict

Interactor 1: XPO1 (O14980)
Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog)
Gene: XPO1

Interactor 2: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CRM1_C~Ras, CRM1_repeat~Ras, CRM1_repeat_2~Ras, IBN_N~Ras, Ras~Xpo1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1071 Hs			1 192
+	Hs
		162565 XPO1_HUMAN (1-1071): 0: 1022: 100.00		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		925496 TNPO1_HUMAN (33-1045): 1.81e-132: 425: 13.84		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		207922 XPOT_HUMAN (29-1023): 3.55e-126: 410: 14.85		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		207925 XPOT_HUMAN (29-1023): 3.55e-126: 410: 14.85		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		207919 XPOT_HUMAN (29-1023): 3.55e-126: 410: 14.85		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Mm
		983320 XPO7_MOUSE (23-1013): 5.43e-120: 397: 13.01		RAC2_MOUSE (1-192): 6.16e-83: 245: 91.67
+	Hs
		925631 XPO5_HUMAN (26-665): 5.8e-100: 344: 16.12		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		925285 IMB1_HUMAN (27-908): 2.89e-90: 311: 11.32		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00