HitPredict

Interactor 1: XPO1 (O14980)
Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog)
Gene: XPO1

Interactor 2: SRSF5 (Q13243)
Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5)
Gene: SRSF5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	26673895
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~Xpo1
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1071 Hs			1 272
+	Hs
		162664 XPO1_HUMAN (1-1071): 0: 1022: 100.00		SRSF1_HUMAN (2-170): 6.55e-57: 184: 43.68
+	Hs
		162698 XPO1_HUMAN (1-1071): 0: 1022: 100.00		SRSF6_HUMAN (5-184): 1.35e-48: 165: 61.96
+	Xl
		1155687 Q6NS03_XENLA (1-1071): 0: 1007: 97.01		Q7ZWX7_XENLA (4-82): 2.01e-29: 111: 42.68
+	Hs
		163222 XPO1_HUMAN (1-1071): 0: 1022: 100.00		RBM4_HUMAN (3-122): 5.32e-17: 81.7: 22.50
+	Hs
		162702 XPO1_HUMAN (1-1071): 0: 1022: 100.00		PABP4_HUMAN (104-189): 3.45e-16: 80.1: 21.98
+	Hs
		162812 XPO1_HUMAN (1-1071): 0: 1022: 100.00		PAP1L_HUMAN (105-189): 5.16e-16: 79.4: 16.67
+	Hs
		162372 XPO1_HUMAN (1-1071): 0: 1022: 100.00		PABP1_HUMAN (98-189): 1.16e-15: 78.6: 18.56
+	Hs
		162636 XPO1_HUMAN (1-1071): 0: 1022: 100.00		TIAR_HUMAN (3-103): 3.49e-12: 67.4: 14.56
+	Xl
		1155766 Q6NS03_XENLA (1-1071): 0: 1007: 97.01		EPABA_XENLA (105-189): 3.13e-14: 74: 17.78
+	Sc
		376677 XPO1_YEAST (14-1067): 0: 848: 46.08		PABP_YEAST (86-192): 7.08e-15: 75.9: 19.64
+	Mm
		1112120 XPO7_MOUSE (23-1013): 5.43e-120: 397: 13.01		SRSF6_MOUSE (5-184): 3.33e-58: 190: 61.96
+	Mm
		1161051 XPO7_MOUSE (23-1013): 5.43e-120: 397: 13.01		SRSF1_MOUSE (2-170): 6.55e-57: 184: 43.68
+	Mm
		1321934 XPO7_MOUSE (23-1013): 5.43e-120: 397: 13.01		SRSF9_MOUSE (2-211): 1.94e-54: 177: 34.42
+	Mm
		192626 XPO7_MOUSE (23-1013): 5.43e-120: 397: 13.01		SRSF5_MOUSE (1-179): 5.42e-54: 177: 100.00
+	Mm
		1257560 XPO7_MOUSE (23-1013): 5.43e-120: 397: 13.01		SRSF4_MOUSE (5-267): 3.29e-46: 163: 53.76
+	At
		955326 MOS14_ARATH (26-1002): 6.38e-104: 350: 13.35		SRS31_ARATH (6-267): 2.4e-48: 162: 27.24
+	At
		186863 MOS14_ARATH (26-1002): 6.38e-104: 350: 13.35		SR34_ARATH (6-268): 3.39e-47: 161: 31.90
+	Dm
		644445 Q9VQG0_DROME (24-1023): 1.78e-89: 309: 12.89		SRR55_DROME (1-179): 1.66e-56: 187: 58.64
+	Mm
		952211 XPO7_MOUSE (23-1013): 5.43e-120: 397: 13.01		SRSF3_MOUSE (4-78): 1.85e-11: 62.8: 47.56
+	At
		1208783 MOS14_ARATH (26-1002): 6.38e-104: 350: 13.35		RSZ33_ARATH (5-80): 2.24e-13: 70.5: 51.32