HitPredict

Interactor 1: XPO1 (O14980)
Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog)
Gene: XPO1

Interactor 2: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	36517590, 19955415
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1071 Hs			1 746
+	Hs
		163234 XPO1_HUMAN (1-1071): 0: 1022: 100.00		SETD2_HUMAN (190-732): 2.07e-89: 310: 16.64
+	Hs
		1080201 TNPO1_HUMAN (33-1045): 1.81e-132: 425: 13.84		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		1060762 IMB1_HUMAN (27-908): 2.89e-90: 311: 11.32		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Mm
		936158 IMB1_MOUSE (27-908): 2.4e-91: 313: 11.43		Q6AXH7_MOUSE (1-746): 0: 832: 96.41
+	Hs
		162652 XPO1_HUMAN (1-1071): 0: 1022: 100.00		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54
+	Mm
		93312 XPO7_MOUSE (23-1013): 5.43e-120: 397: 13.01		SET1A_MOUSE (611-732): 2.47e-18: 92.4: 38.71