Interactor 1: CHK1 (O14757)
Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Cell cycle checkpoint kinase) (Checkpoint kinase-1)
Gene: CHEK1
Interactor 2: PPM1D (O15297)
Protein phosphatase 1D (EC 3.1.3.16) (Protein phosphatase 2C isoform delta) (PP2C-delta) (Protein phosphatase magnesium-dependent 1 delta) (p53-induced protein phosphatase 1)
Gene: PPM1D
Species: Homo sapiens
Source: biogrid
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.52 | 1.00 | 0.724 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 15870257 |
| Identification Methods | enzymatic study, affinity chromatography technology |
| Interaction Type | direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | PP2C~Pkinase |
| Common GO terms | GO:0000086 - G2/M transition of mitotic cell cycle GO:0004674 - protein serine/threonine kinase activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol and 1 others more... |
| Homologous interactions | 5 |
Homologous interactions
Color coding for hit scores 
|
|
|||||||||||||
| + | At |   |
|
|||||||||||
| + | At | |
 |
|||||||||||
| + | At | |
|
|||||||||||
| + | At |  |
|
|||||||||||
| + | At | |
|
|||||||||||
Service provided by Combinatics, Japan
Last updated: 11Aug2025
