HitPredict

Interactor 1: ARHGA (O15013)
Rho guanine nucleotide exchange factor 10
Gene: ARHGEF10

Interactor 2: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	32203420
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ras~RhoGEF
Common GO terms	GO:0005813 - centrosome GO:0005829 - cytosol GO:0030036 - actin cytoskeleton organization GO:0051496 - positive regulation of stress fiber assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1369 Hs			1 191
+	Hs
		164115 ARHGA_HUMAN (1-1369): 0: 1178: 100.00		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		164112 ARHGA_HUMAN (1-1369): 0: 1178: 100.00		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		900813 ARHGH_HUMAN (22-1290): 1.73e-167: 553: 16.60		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		894047 ITSN1_HUMAN (55-832): 2.19e-100: 356: 15.02		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		564737 PKHG1_HUMAN (363-1052): 2.37e-92: 329: 13.65		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Hs
		925527 SPT13_HUMAN (176-845): 8.12e-104: 346: 16.37		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		894323 SPT13_HUMAN (176-845): 8.12e-104: 346: 16.37		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		925649 ARHG4_HUMAN (139-858): 3.13e-97: 329: 14.52		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		925727 PKHG1_HUMAN (363-1052): 2.37e-92: 329: 13.65		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		1078851 ITSN1_HUMAN (55-832): 2.19e-100: 356: 15.02		RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82
+	Hs
		925512 ARHGQ_HUMAN (27-773): 6.23e-95: 328: 16.69		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		156397 RGRF2_HUMAN (332-733): 5.55e-92: 326: 21.88		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		900679 ARG28_HUMAN (20-983): 3.41e-93: 334: 11.86		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		894480 ARHG4_HUMAN (139-858): 3.13e-97: 329: 14.52		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		894583 PKHG1_HUMAN (363-1052): 2.37e-92: 329: 13.65		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		894301 ARHGQ_HUMAN (27-773): 6.23e-95: 328: 16.69		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		156394 RGRF2_HUMAN (332-733): 5.55e-92: 326: 21.88		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		900947 ARHG4_HUMAN (139-858): 3.13e-97: 329: 14.52		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		900786 ARHGQ_HUMAN (27-773): 6.23e-95: 328: 16.69		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		156395 RGRF2_HUMAN (332-733): 5.55e-92: 326: 21.88		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48