HitPredict

Interactor 1: SPTN2 (O15020)
Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein)
Gene: SPTBN2

Interactor 2: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030036 - actin cytoskeleton organization GO:0030054 - cell junction GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2390 Hs			1 193
+	Hs
		164599 SPTN2_HUMAN (1-2390): 0: 715: 100.00		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		900386 SPTB2_HUMAN (3-2390): 0: 712: 61.09		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		925201 SPTB2_HUMAN (3-2390): 0: 712: 61.09		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		164556 SPTN2_HUMAN (1-2390): 0: 715: 100.00		RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71
+	Hs
		164602 SPTN2_HUMAN (1-2390): 0: 715: 100.00		RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40
+	Hs
		164590 SPTN2_HUMAN (1-2390): 0: 715: 100.00		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		436258 SPTB2_HUMAN (3-2390): 0: 712: 61.09		RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71
+	Hs
		950929 SPTB2_HUMAN (3-2390): 0: 712: 61.09		RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40
+	Hs
		893910 SPTB2_HUMAN (3-2390): 0: 712: 61.09		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		545327 SPTB2_HUMAN (3-2390): 0: 712: 61.09		RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61
+	Hs
		164589 SPTN2_HUMAN (1-2390): 0: 715: 100.00		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Hs
		164598 SPTN2_HUMAN (1-2390): 0: 715: 100.00		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Hs
		892322 SPTB2_HUMAN (3-2390): 0: 712: 61.09		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Hs
		915613 SPTB2_HUMAN (3-2390): 0: 712: 61.09		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Hs
		120207 SPTN2_HUMAN (1-2390): 0: 715: 100.00		RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98
+	Hs
		120393 SPTB2_HUMAN (3-2390): 0: 712: 61.09		RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98
+	Hs
		436196 UTRN_HUMAN (19-2308): 3.65e-86: 318: 14.19		RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71
+	Hs
		545254 UTRN_HUMAN (19-2308): 3.65e-86: 318: 14.19		RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61
+	Hs
		809091 UTRN_HUMAN (19-2308): 3.65e-86: 318: 14.19		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Hs
		120338 UTRN_HUMAN (19-2308): 3.65e-86: 318: 14.19		RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98