HitPredict

Interactor 1: SPTN2 (O15020)
Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein)
Gene: SPTBN2

Interactor 2: PP1B (P62140)
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53)
Gene: PPP1CB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 2390 Hs			1 327
+	Hs
		906417 SPTB2_HUMAN (3-2390): 0: 712: 61.09		PP1B_HUMAN (1-327): 0: 597: 100.00
+	Hs
		737749 SPTB2_HUMAN (3-2390): 0: 712: 61.09		PP1G_HUMAN (1-327): 0: 569: 86.89
+	Hs
		211552 ACTN4_HUMAN (56-621): 3.25e-122: 412: 41.70		PP1B_HUMAN (1-327): 0: 597: 100.00
+	Hs
		521519 ACTN1_HUMAN (31-766): 7.87e-88: 310: 32.02		PP1B_HUMAN (1-327): 0: 597: 100.00
+	Hs
		906448 SPTN1_HUMAN (279-2273): 5.34e-78: 291: 18.75		PP1B_HUMAN (1-327): 0: 597: 100.00
+	Mm
		561155 SPTN1_MOUSE (279-2273): 1.18e-78: 293: 19.03		PP1A_MOUSE (1-326): 0: 576: 88.49
+	Hs
		906466 PLEC_HUMAN (379-2232): 1.33e-50: 201: 10.46		PP1B_HUMAN (1-327): 0: 597: 100.00
+	Dm
		819270 Q7KV70_DROME (452-2383): 2.29e-53: 210: 15.05		PP1B_DROME (1-322): 0: 568: 90.37
+	Hs
		737818 PLEC_HUMAN (379-2232): 1.33e-50: 201: 10.46		PP1G_HUMAN (1-327): 0: 569: 86.89
+	Dm
		1249935 Q9VZQ3_DROME (452-2383): 2.29e-53: 210: 15.05		Q8T0U6_DROME (18-322): 0: 550: 91.48
+	Hs
		906420 DYST_HUMAN (1807-2150): 4.68e-11: 71: 13.35		PP1B_HUMAN (1-327): 0: 597: 100.00