HitPredict

Interactor 1: SPTN2 (O15020)
Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein)
Gene: SPTBN2

Interactor 2: NEMO (Q9Y6K9)
NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: IKBKG

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2390 Hs			1 419
+	Hs
		963335 SPTB2_HUMAN (3-2390): 0: 712: 61.09		ITSN1_HUMAN (24-403): 1.07e-30: 127: 12.15
+	Hs
		164575 SPTN2_HUMAN (1-2390): 0: 715: 100.00		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93
+	Hs
		724781 SPTB2_HUMAN (3-2390): 0: 712: 61.09		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93
+	Hs
		164647 SPTN2_HUMAN (1-2390): 0: 715: 100.00		MY18A_HUMAN (10-390): 4.23e-09: 60.8: 15.89
+	Hs
		963381 SPTB2_HUMAN (3-2390): 0: 712: 61.09		MY18A_HUMAN (10-390): 4.23e-09: 60.8: 15.89
+	Mm
		93541 SPTA1_MOUSE (814-2098): 4.64e-123: 438: 19.03		DESP_MOUSE (49-376): 9.41e-09: 60: 17.60
+	Hs
		211515 ACTN4_HUMAN (56-621): 3.25e-122: 412: 41.70		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93
+	Hs
		211632 ACTN4_HUMAN (56-621): 3.25e-122: 412: 41.70		MY18A_HUMAN (10-390): 4.23e-09: 60.8: 15.89
+	Hs
		1045423 SPTN1_HUMAN (279-2273): 5.34e-78: 291: 18.75		ITSN1_HUMAN (24-403): 1.07e-30: 127: 12.15
+	Hs
		521484 ACTN1_HUMAN (31-766): 7.87e-88: 310: 32.02		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93
+	Hs
		724817 SPTN1_HUMAN (279-2273): 5.34e-78: 291: 18.75		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93
+	Hs
		522612 SPTN1_HUMAN (279-2273): 5.34e-78: 291: 18.75		MYH7_HUMAN (26-376): 1.58e-09: 62.3: 13.24
+	Hs
		1045471 SPTN1_HUMAN (279-2273): 5.34e-78: 291: 18.75		MY18A_HUMAN (10-390): 4.23e-09: 60.8: 15.89
+	Hs
		1068591 PLEC_HUMAN (379-2232): 1.33e-50: 201: 10.46		MY18B_HUMAN (35-415): 6.59e-31: 127: 13.46
+	Hs
		724839 PLEC_HUMAN (379-2232): 1.33e-50: 201: 10.46		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93
+	Mm
		93578 PLEC_MOUSE (379-2203): 7.98e-51: 202: 10.89		DESP_MOUSE (49-376): 9.41e-09: 60: 17.60
+	Hs
		1068617 PLEC_HUMAN (379-2232): 1.33e-50: 201: 10.46		MY18A_HUMAN (10-390): 4.23e-09: 60.8: 15.89
+	Hs
		974083 DYST_HUMAN (1807-2150): 4.68e-11: 71: 13.35		ITSN1_HUMAN (24-403): 1.07e-30: 127: 12.15
+	Mm
		513804 DMD_MOUSE (231-1491): 4.57e-15: 84.5: 10.70		FYCO1_MOUSE (45-371): 5.61e-20: 94.7: 17.07
+	Hs
		724786 DYST_HUMAN (1807-2150): 4.68e-11: 71: 13.35		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93