HitPredict

Interactor 1: MAST4 (O15021)
Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1)
Gene: MAST4

Interactor 2: SMAD1 (Q15797)
Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)
Gene: SMAD1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.60	0.508

Property	Details
Experiments	15231748
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2623 Hs			1 465
+	Hs
		1035199 ROCK1_HUMAN (551-1673): 1.03e-179: 593: 17.80		SMAD5_HUMAN (2-465): 0: 619: 89.46
+	Hs
		1035175 ROCK1_HUMAN (551-1673): 1.03e-179: 593: 17.80		SMAD2_HUMAN (3-465): 0: 541: 55.14
+	Mm
		472973 KGP1_MOUSE (441-898): 3.51e-128: 422: 29.09		SMAD1_MOUSE (1-465): 0: 656: 99.14
+	Hs
		254477 ROCK2_HUMAN (480-1667): 0: 609: 17.52		SMAD4_HUMAN (13-454): 1.6e-150: 441: 34.28
+	Hs
		1035168 ROCK1_HUMAN (551-1673): 1.03e-179: 593: 17.80		SMAD4_HUMAN (13-454): 1.6e-150: 441: 34.28
+	Hs
		950333 SIK3_HUMAN (550-1763): 1.96e-139: 475: 15.45		SMAD3_HUMAN (3-465): 0: 556: 59.66
+	Hs
		1078701 SIK3_HUMAN (550-1763): 1.96e-139: 475: 15.45		SMAD2_HUMAN (3-465): 0: 541: 55.14
+	Hs
		681788 AKT1_HUMAN (437-905): 6.22e-144: 460: 27.82		SMAD3_HUMAN (3-465): 0: 556: 59.66
+	Hs
		1078680 LATS2_HUMAN (28-943): 1.77e-141: 474: 21.60		SMAD2_HUMAN (3-465): 0: 541: 55.14
+	Mm
		682117 AKT1_MOUSE (437-905): 6.92e-144: 459: 27.82		SMAD3_MOUSE (3-465): 0: 556: 59.66
+	Rn
		812704 AKT1_RAT (437-905): 1.08e-143: 459: 28.03		SMAD3_RAT (3-465): 0: 556: 59.66
+	Rn
		250835 AKT1_RAT (437-905): 1.08e-143: 459: 28.03		SMAD2_RAT (3-465): 0: 542: 55.14
+	Hs
		681864 AKT1_HUMAN (437-905): 6.22e-144: 460: 27.82		SMAD2_HUMAN (3-465): 0: 541: 55.14
+	Hs
		1035470 MRCKG_HUMAN (515-1561): 1.09e-146: 502: 20.71		SMAD4_HUMAN (13-454): 1.6e-150: 441: 34.28
+	Rn
		250838 AKT1_RAT (437-905): 1.08e-143: 459: 28.03		SMAD4_RAT (13-454): 1.9e-152: 446: 34.66
+	Hs
		681832 AKT1_HUMAN (437-905): 6.22e-144: 460: 27.82		SMAD4_HUMAN (13-454): 1.6e-150: 441: 34.28
+	Hs
		1035485 MARK2_HUMAN (514-1191): 3.99e-138: 455: 21.08		SMAD4_HUMAN (13-454): 1.6e-150: 441: 34.28
+	Mm
		472974 KGP1_MOUSE (441-898): 3.51e-128: 422: 29.09		SMAD4_MOUSE (13-454): 7.4e-151: 442: 34.66
+	Hs
		167333 AKT1_HUMAN (437-905): 6.22e-144: 460: 27.82		SMAD7_HUMAN (30-131): 2.89e-25: 109: 32.46
+	Rn
		291521 AKT1_RAT (437-905): 1.08e-143: 459: 28.03		SMAD7_RAT (30-131): 1.23e-24: 107: 33.33