HitPredict

Interactor 1: PLXB2 (O15031)
Plexin-B2 (MM1)
Gene: PLXNB2

Interactor 2: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Plexin_cytopl~Ras, Plexin_RBD~Ras, Ras~TIG
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1838 Hs			1 189
+	Hs
		165201 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28
+	Hs
		165181 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97
+	Hs
		253442 PLXA2_HUMAN (17-1832): 0: 2080: 31.48		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		349716 PLXA1_HUMAN (12-1831): 0: 2078: 32.31		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		348992 PLXA1_HUMAN (12-1831): 0: 2078: 32.31		RASN_HUMAN (1-189): 2.37e-85: 251: 85.19
+	Hs
		1070445 PLXA1_HUMAN (12-1831): 0: 2078: 32.31		RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28
+	Hs
		253443 PLXA2_HUMAN (17-1832): 0: 2080: 31.48		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		350661 PLXA1_HUMAN (12-1831): 0: 2078: 32.31		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Dm
		381633 Q0KIF1_DROME (389-1834): 0: 1751: 33.12		RAS2_DROME (1-189): 2.25e-55: 175: 54.92
+	Hs
		349625 SEM4C_HUMAN (1-570): 3.64e-139: 456: 18.82		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		348909 SEM4C_HUMAN (1-570): 3.64e-139: 456: 18.82		RASN_HUMAN (1-189): 2.37e-85: 251: 85.19
+	Hs
		1070385 SEM4C_HUMAN (1-570): 3.64e-139: 456: 18.82		RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28
+	Hs
		348915 SEM6A_HUMAN (5-518): 7.22e-131: 438: 18.80		RASN_HUMAN (1-189): 2.37e-85: 251: 85.19
+	Hs
		350524 SEM4C_HUMAN (1-570): 3.64e-139: 456: 18.82		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		348840 SEM4D_HUMAN (1-539): 7.77e-131: 433: 17.12		RASN_HUMAN (1-189): 2.37e-85: 251: 85.19
+	Hs
		914341 SEM4C_HUMAN (1-570): 3.64e-139: 456: 18.82		RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88
+	Mm
		914512 SEM4A_MOUSE (23-608): 1.01e-138: 452: 18.43		RB11A_MOUSE (4-184): 2.43e-72: 219: 33.88
+	Hs
		350538 SEM6A_HUMAN (5-518): 7.22e-131: 438: 18.80		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		350423 SEM4D_HUMAN (1-539): 7.77e-131: 433: 17.12		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		234719 PLXC1_HUMAN (21-856): 3.31e-104: 371: 19.65		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00