HitPredict

Interactor 1: PLXB2 (O15031)
Plexin-B2 (MM1)
Gene: PLXNB2

Interactor 2: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Plexin_cytopl~Ras, Plexin_RBD~Ras, Ras~TIG
Common GO terms	GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1838 Hs			1 191
+	Hs
		165157 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Hs
		165251 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17
+	Hs
		165187 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		165189 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73
+	Hs
		165182 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		165155 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		165146 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41
+	Hs
		165179 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Hs
		165218 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82
+	Hs
		1330978 PLXA1_HUMAN (12-1831): 0: 2078: 32.31		RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17
+	Hs
		925714 PLXA1_HUMAN (12-1831): 0: 2078: 32.31		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		894567 PLXA1_HUMAN (12-1831): 0: 2078: 32.31		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		951446 PLXA1_HUMAN (12-1831): 0: 2078: 32.31		RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73
+	Hs
		901031 PLXA1_HUMAN (12-1831): 0: 2078: 32.31		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		545690 PLXA1_HUMAN (12-1831): 0: 2078: 32.31		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		436563 PLXA1_HUMAN (12-1831): 0: 2078: 32.31		RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41
+	Hs
		892670 PLXA1_HUMAN (12-1831): 0: 2078: 32.31		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Hs
		1183600 PLXA1_HUMAN (12-1831): 0: 2078: 32.31		RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82
+	Dm
		776907 PLXB_DROME (28-1836): 0: 1803: 29.30		RAC1_DROME (1-191): 1.02e-81: 242: 69.27
+	Dm
		816387 PLXB_DROME (28-1836): 0: 1803: 29.30		RHO1_DROME (5-191): 1.18e-77: 231: 54.55