HitPredict

Interactor 1: PLXB2 (O15031)
Plexin-B2 (MM1)
Gene: PLXNB2

Interactor 2: RHOG (P84095)
Rho-related GTP-binding protein RhoG
Gene: RHOG

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Plexin_cytopl~Ras, Plexin_RBD~Ras, Ras~TIG
Common GO terms	GO:0005886 - plasma membrane GO:0008360 - regulation of cell shape GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1838 Hs			1 191
+	Hs
		165187 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88
+	Hs
		165155 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		RAC2_HUMAN (1-191): 1.28e-78: 234: 71.35
+	Hs
		165180 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		CDC42_HUMAN (1-191): 1.3e-78: 234: 60.73
+	Hs
		165182 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		RHOA_HUMAN (5-191): 1.26e-78: 234: 55.62
+	Hs
		165146 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		RHOC_HUMAN (5-191): 8.34e-77: 230: 56.15
+	Hs
		165179 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		RAC3_HUMAN (1-177): 1.67e-75: 226: 72.88
+	Hs
		165157 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		RHOQ_HUMAN (4-189): 5.74e-73: 220: 56.84
+	Hs
		925714 PLXA1_HUMAN (12-1831): 0: 2078: 32.31		RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88
+	Hs
		951446 PLXA1_HUMAN (12-1831): 0: 2078: 32.31		RHOG_HUMAN (1-191): 9.12e-82: 242: 100.00
+	Hs
		545690 PLXA1_HUMAN (12-1831): 0: 2078: 32.31		RAC2_HUMAN (1-191): 1.28e-78: 234: 71.35
+	Hs
		894567 PLXA1_HUMAN (12-1831): 0: 2078: 32.31		CDC42_HUMAN (1-191): 1.3e-78: 234: 60.73
+	Hs
		901031 PLXA1_HUMAN (12-1831): 0: 2078: 32.31		RHOA_HUMAN (5-191): 1.26e-78: 234: 55.62
+	Hs
		436563 PLXA1_HUMAN (12-1831): 0: 2078: 32.31		RHOC_HUMAN (5-191): 8.34e-77: 230: 56.15
+	Hs
		892670 PLXA1_HUMAN (12-1831): 0: 2078: 32.31		RAC3_HUMAN (1-177): 1.67e-75: 226: 72.88
+	Dm
		776907 PLXB_DROME (28-1836): 0: 1803: 29.30		RAC1_DROME (1-191): 5.32e-79: 235: 67.71
+	Dm
		819748 PLXB_DROME (28-1836): 0: 1803: 29.30		RAC2_DROME (1-191): 7.11e-78: 232: 67.71
+	Dm
		816387 PLXB_DROME (28-1836): 0: 1803: 29.30		RHO1_DROME (5-191): 6.13e-75: 225: 56.68
+	Hs
		564678 SEM6A_HUMAN (5-518): 7.22e-131: 438: 18.80		RHOQ_HUMAN (4-189): 5.74e-73: 220: 56.84
+	Hs
		441478 MET_HUMAN (746-1153): 4.48e-87: 316: 21.38		RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88
+	Hs
		436125 MET_HUMAN (746-1153): 4.48e-87: 316: 21.38		RHOC_HUMAN (5-191): 8.34e-77: 230: 56.15