HitPredict

Interactor 1: SET1A (O15047)
Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1)
Gene: SETD1A

Interactor 2: SMCA1 (P28370)
Probable global transcription activator SNF2L1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA1) (Nucleosome-remodeling factor subunit SNF2L) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1)
Gene: SMARCA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	21653943
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0007420 - brain development GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1707 Hs			1 1054
+	Hs
		658681 EZH2_HUMAN (1161-1690): 6.02e-75: 268: 14.71		SMCA1_HUMAN (1-1054): 0: 1130: 100.00
+	Hs
		165677 SET1A_HUMAN (1-1707): 6.31e-168: 556: 100.00		CHD4_HUMAN (29-960): 0: 789: 28.27
+	Hs
		229411 EZH2_HUMAN (1161-1690): 6.02e-75: 268: 14.71		SMCA5_HUMAN (32-1051): 0: 1065: 81.86
+	Hs
		165721 SET1A_HUMAN (1-1707): 6.31e-168: 556: 100.00		CHD8_HUMAN (2-1011): 0: 769: 27.72
+	Sc
		744865 SET1_YEAST (1286-1707): 1.12e-70: 261: 27.36		ISW1_YEAST (70-1049): 0: 805: 47.63
+	Mm
		1125396 Q6AXH7_MOUSE (1163-1690): 2.64e-76: 272: 14.81		Q5DTP7_MOUSE (29-960): 0: 789: 28.27
+	Hs
		1018505 EZH2_HUMAN (1161-1690): 6.02e-75: 268: 14.71		CHD3_HUMAN (31-954): 0: 791: 28.94
+	Hs
		1059639 EZH2_HUMAN (1161-1690): 6.02e-75: 268: 14.71		CHD4_HUMAN (29-960): 0: 789: 28.27
+	Hs
		975235 KMT2A_HUMAN (1094-1707): 3.48e-69: 261: 21.28		CHD3_HUMAN (31-954): 0: 791: 28.94
+	Hs
		975252 KMT2A_HUMAN (1094-1707): 3.48e-69: 261: 21.28		CHD4_HUMAN (29-960): 0: 789: 28.27
+	Hs
		1080420 EZH2_HUMAN (1161-1690): 6.02e-75: 268: 14.71		CHD7_HUMAN (3-1046): 0: 780: 26.74
+	Hs
		203687 SUV91_HUMAN (1506-1706): 1.66e-73: 253: 22.75		CHD4_HUMAN (29-960): 0: 789: 28.27
+	Hs
		1080369 EZH2_HUMAN (1161-1690): 6.02e-75: 268: 14.71		CHD8_HUMAN (2-1011): 0: 769: 27.72
+	Hs
		1080145 EZH2_HUMAN (1161-1690): 6.02e-75: 268: 14.71		CHD6_HUMAN (1-1039): 0: 750: 26.80
+	Hs
		151495 EZH2_HUMAN (1161-1690): 6.02e-75: 268: 14.71		CHD2_HUMAN (21-1047): 0: 732: 29.60
+	Hs
		151417 EZH2_HUMAN (1161-1690): 6.02e-75: 268: 14.71		CHD1_HUMAN (5-1050): 0: 695: 29.33
+	Hs
		846983 EZH2_HUMAN (1161-1690): 6.02e-75: 268: 14.71		SMCA4_HUMAN (60-913): 0: 686: 31.42
+	Hs
		846784 EZH2_HUMAN (1161-1690): 6.02e-75: 268: 14.71		SMCA2_HUMAN (170-669): 1.05e-122: 413: 44.32
+	Sc
		696209 SET1_YEAST (1286-1707): 1.12e-70: 261: 27.36		STH1_YEAST (170-695): 4.13e-124: 413: 45.69
+	Hs
		846753 KMT2A_HUMAN (1094-1707): 3.48e-69: 261: 21.28		SMCA2_HUMAN (170-669): 1.05e-122: 413: 44.32