HitPredict

Interactor 1: SET1A (O15047)
Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1)
Gene: SETD1A

Interactor 2: WDR5 (P61964)
WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)
Gene: WDR5

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.987

Property	Details
Experiments	23453808, 23870121, 27563068, 29474905, 31076518, 24981860, 17355966, 22665483, 26186194, 28514442, 27705803, 33022573, 33961781, 16253997, 33472061, 20305087, 22266653, 15960975
Identification Methods	pull down, affinity chromatography technology, unspecified method, x-ray crystallography, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	N-SET~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0035097 - histone methyltransferase complex GO:0042800 - histone H3K4 methyltransferase activity GO:0048188 - Set1C/COMPASS complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1707 Hs			1 334
+	Hs
		903604 KMT2B_HUMAN (1010-1707): 4.16e-74: 277: 22.55		WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00
+	Hs
		903149 KMT2A_HUMAN (1094-1707): 3.48e-69: 261: 21.28		WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00
+	Hs
		903609 SET1B_HUMAN (257-1707): 2.03e-55: 216: 23.18		WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00
+	Hs
		209441 EZH2_HUMAN (1161-1690): 6.02e-75: 268: 14.71		PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05
+	Dm
		1129076 SET1_DROME (18-215): 6.29e-54: 210: 34.67		WDS_DROME (3-290): 7.53e-92: 279: 31.21
+	At
		1319861 ATX1_ARATH (1473-1707): 3.76e-65: 244: 31.41		WDR5A_ARATH (2-241): 2.46e-75: 236: 27.82
+	Hs
		152622 KMT2D_HUMAN (1567-1707): 6.69e-18: 93.2: 46.15		WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00
+	Mm
		903669 KMT2C_MOUSE (419-1364): 5.59e-09: 63.6: 13.48		WDR5_MOUSE (1-334): 2.77e-131: 379: 100.00
+	Sc
		744551 SET1_YEAST (1286-1707): 1.12e-70: 261: 27.36		SWD3_YEAST (29-330): 8.4e-45: 157: 34.47
+	Hs
		203735 SUV91_HUMAN (1506-1706): 1.66e-73: 253: 22.75		DAW1_HUMAN (144-333): 8.06e-44: 157: 30.69
+	Hs
		1080207 EZH2_HUMAN (1161-1690): 6.02e-75: 268: 14.71		FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15
+	Hs
		975303 KMT2A_HUMAN (1094-1707): 3.48e-69: 261: 21.28		FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15
+	Hs
		1288387 KMT2B_HUMAN (1010-1707): 4.16e-74: 277: 22.55		SNR40_HUMAN (248-333): 6.9e-13: 70.4: 25.29
+	Sp
		195053 SET1_SCHPO (1173-1707): 7.33e-76: 275: 27.60		SWD3_SCHPO (166-330): 1.84e-12: 69.3: 30.30
+	Hs
		975304 KMT2A_HUMAN (1094-1707): 3.48e-69: 261: 21.28		SNR40_HUMAN (248-333): 6.9e-13: 70.4: 25.29
+	Hs
		331862 NSD2_HUMAN (1405-1706): 1.62e-63: 241: 19.94		SNR40_HUMAN (248-333): 6.9e-13: 70.4: 25.29
+	Zm
		35725 A0A1D6M742_MAIZE (1110-1704): 9.65e-64: 233: 13.10		A0A1D6LQJ4_MAIZE (248-333): 5.86e-14: 73.4: 28.41
+	Hs
		152663 KMT2D_HUMAN (1567-1707): 6.69e-18: 93.2: 46.15		WDR5B_HUMAN (3-198): 4.87e-59: 194: 30.10
+	Hs
		1288292 NSD3_HUMAN (1561-1706): 5.1e-55: 213: 30.20		SNR40_HUMAN (248-333): 6.9e-13: 70.4: 25.29
+	Hs
		152678 KMT2D_HUMAN (1567-1707): 6.69e-18: 93.2: 46.15		FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15