HitPredict

Interactor 1: SET1A (O15047)
Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1)
Gene: SETD1A

Interactor 2: RBBP4 (Q09028)
Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48)
Gene: RBBP4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31076518
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	N-SET~WD40
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0007420 - brain development
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1707 Hs			1 425
+	Hs
		997924 ASH1L_HUMAN (140-1706): 1.39e-88: 324: 11.66		RBBP4_HUMAN (1-425): 4.3e-124: 367: 100.00
+	Hs
		165657 SET1A_HUMAN (1-1707): 6.31e-168: 556: 100.00		WDR5_HUMAN (267-425): 7.48e-35: 133: 25.61
+	Hs
		165711 SET1A_HUMAN (1-1707): 6.31e-168: 556: 100.00		GRWD1_HUMAN (263-425): 3.54e-26: 111: 23.56
+	Mm
		1141935 Q6AXH7_MOUSE (1163-1690): 2.64e-76: 272: 14.81		RBBP4_MOUSE (1-425): 4.3e-124: 367: 100.00
+	Mm
		1141929 EZH2_MOUSE (1163-1690): 2.57e-75: 269: 14.95		RBBP4_MOUSE (1-425): 4.3e-124: 367: 100.00
+	Hs
		997735 EZH2_HUMAN (1161-1690): 6.02e-75: 268: 14.71		RBBP4_HUMAN (1-425): 4.3e-124: 367: 100.00
+	Mm
		936646 EZH1_MOUSE (1187-1690): 1.87e-74: 266: 15.04		RBBP4_MOUSE (1-425): 4.3e-124: 367: 100.00
+	Hs
		997839 EZH1_HUMAN (1347-1690): 5.46e-74: 265: 18.64		RBBP4_HUMAN (1-425): 4.3e-124: 367: 100.00
+	Hs
		975233 KMT2A_HUMAN (1094-1707): 3.48e-69: 261: 21.28		RBBP4_HUMAN (1-425): 4.3e-124: 367: 100.00
+	Mm
		1141960 Q6AXH7_MOUSE (1163-1690): 2.64e-76: 272: 14.81		RBBP7_MOUSE (1-425): 1.21e-114: 343: 89.20
+	Hs
		1079986 EZH2_HUMAN (1161-1690): 6.02e-75: 268: 14.71		RBBP7_HUMAN (1-425): 3.63e-115: 345: 89.20
+	Mm
		1141957 EZH2_MOUSE (1163-1690): 2.57e-75: 269: 14.95		RBBP7_MOUSE (1-425): 1.21e-114: 343: 89.20
+	Hs
		1083337 EZH1_HUMAN (1347-1690): 5.46e-74: 265: 18.64		RBBP7_HUMAN (1-425): 3.63e-115: 345: 89.20
+	Mm
		936647 EZH1_MOUSE (1187-1690): 1.87e-74: 266: 15.04		RBBP7_MOUSE (1-425): 1.21e-114: 343: 89.20
+	Hs
		975266 KMT2A_HUMAN (1094-1707): 3.48e-69: 261: 21.28		RBBP7_HUMAN (1-425): 3.63e-115: 345: 89.20
+	Hs
		267764 EZH2_HUMAN (1161-1690): 6.02e-75: 268: 14.71		TAF5L_HUMAN (26-422): 3e-74: 244: 22.20
+	Hs
		903604 KMT2B_HUMAN (1010-1707): 4.16e-74: 277: 22.55		WDR5_HUMAN (267-425): 7.48e-35: 133: 25.61
+	Dm
		1099178 ASH1_DROME (871-1706): 3.35e-75: 280: 16.38		CAF1_DROME (226-419): 3.68e-29: 119: 18.36
+	Hs
		903149 KMT2A_HUMAN (1094-1707): 3.48e-69: 261: 21.28		WDR5_HUMAN (267-425): 7.48e-35: 133: 25.61
+	Ce
		219656 LIN59_CAEEL (1126-1706): 9.15e-71: 264: 19.32		LIN53_CAEEL (272-421): 6.33e-22: 99.1: 21.52