HitPredict

Interactor 1: KDM6B (O15054)
Lysine-specific demethylase 6B (EC 1.14.11.68) (JmjC domain-containing protein 3) (Jumonji domain-containing protein 3) (Lysine demethylase 6B) ([histone H3]-trimethyl-L-lysine(27) demethylase 6B)
Gene: KDM6B

Interactor 2: H31 (P68431)
Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)
Gene: H3C1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	17713478
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1643 Hs			1 136
+	Mm
		952745 KDM6B_MOUSE (1-1643): 2.09e-163: 541: 88.77		H33_MOUSE (1-136): 2.73e-61: 186: 96.32
+	Hs
		183098 KDM6A_HUMAN (1-647): 1.77e-50: 199: 14.24		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		183122 KDM6A_HUMAN (1-647): 1.77e-50: 199: 14.24		H31T_HUMAN (1-136): 1.27e-61: 187: 97.06
+	Hs
		183127 KDM6A_HUMAN (1-647): 1.77e-50: 199: 14.24		H32_HUMAN (1-136): 6.5e-61: 185: 99.27
+	Hs
		935066 CBP_HUMAN (35-1003): 1.04e-25: 118: 11.05		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		1086253 CBP_HUMAN (35-1003): 1.04e-25: 118: 11.05		H31T_HUMAN (1-136): 1.27e-61: 187: 97.06
+	Hs
		934763 MDC1_HUMAN (304-1327): 2.36e-23: 110: 10.94		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		952338 MDC1_HUMAN (304-1327): 2.36e-23: 110: 10.94		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		935378 SRRM2_HUMAN (324-1330): 8.25e-13: 76.1: 10.52		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Mm
		101827 F8WI37_MOUSE (676-1313): 2.39e-13: 78: 9.31		H33_MOUSE (1-136): 2.73e-61: 186: 96.32
+	Hs
		934684 IF4G1_HUMAN (553-1078): 1.29e-12: 75.3: 18.02		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		935004 KMT2C_HUMAN (238-1185): 1.59e-12: 75.2: 12.41		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		1086228 KMT2C_HUMAN (238-1185): 1.59e-12: 75.2: 12.41		H31T_HUMAN (1-136): 1.27e-61: 187: 97.06
+	Hs
		952479 KMT2C_HUMAN (238-1185): 1.59e-12: 75.2: 12.41		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		1174692 SRRM2_HUMAN (324-1330): 8.25e-13: 76.1: 10.52		H32_HUMAN (1-136): 6.5e-61: 185: 99.27
+	Hs
		1174600 KMT2C_HUMAN (238-1185): 1.59e-12: 75.2: 12.41		H32_HUMAN (1-136): 6.5e-61: 185: 99.27
+	Hs
		828275 ANR11_HUMAN (442-1102): 2.07e-16: 88: 19.13		CENPA_HUMAN (9-133): 5.62e-45: 145: 50.00
+	Sc
		730797 SEC31_YEAST (254-682): 6.34e-11: 69.9: 17.31		CENPA_YEAST (18-134): 2.12e-41: 138: 55.83