HitPredict

Interactor 1: KDM6B (O15054)
Lysine-specific demethylase 6B (EC 1.14.11.68) (JmjC domain-containing protein 3) (Jumonji domain-containing protein 3) (Lysine demethylase 6B) ([histone H3]-trimethyl-L-lysine(27) demethylase 6B)
Gene: KDM6B

Interactor 2: RBBP5 (Q15291)
Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3)
Gene: RBBP5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17825402
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0044666 - MLL3/4 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1643 Hs			1 538
+	Mm
		1129461 KDM6B_MOUSE (1-1643): 2.09e-163: 541: 88.77		RBBP5_MOUSE (1-538): 9.56e-137: 408: 99.07
+	Ce
		1089275 JMJ31_CAEEL (844-1634): 6.17e-156: 506: 20.34		WDR51_CAEEL (140-424): 4.13e-47: 170: 13.29
+	Hs
		165835 KDM6B_HUMAN (1-1643): 3.88e-172: 565: 100.00		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41
+	Hs
		150102 UTY_HUMAN (1-588): 2.61e-53: 208: 14.15		RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00
+	Hs
		183118 KDM6A_HUMAN (1-647): 1.77e-50: 199: 14.24		RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00
+	Hs
		1070752 CBP_HUMAN (35-1003): 1.04e-25: 118: 11.05		RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00
+	Dm
		114497 M9PCJ7_DROME (1-249): 1.94e-30: 133: 17.10		RBBP5_DROME (1-494): 3.54e-103: 320: 65.79
+	Ca
		483035 Q5ADP3_CANAL (22-728): 9.3e-30: 131: 11.30		TUP1_CANAL (100-402): 3.81e-53: 190: 16.10
+	Hs
		183146 KDM6A_HUMAN (1-647): 1.77e-50: 199: 14.24		FBXW7_HUMAN (279-521): 2.8e-16: 83.9: 10.56
+	Hs
		150096 UTY_HUMAN (1-588): 2.61e-53: 208: 14.15		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41
+	Hs
		183095 KDM6A_HUMAN (1-647): 1.77e-50: 199: 14.24		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41
+	Hs
		99745 F5H5V6_HUMAN (1-609): 3.3e-50: 197: 17.95		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41
+	Dm
		114491 M9PCJ7_DROME (1-249): 1.94e-30: 133: 17.10		WDS_DROME (250-438): 1.02e-21: 98.5: 10.82
+	Hs
		1056932 MDC1_HUMAN (304-1327): 2.36e-23: 110: 10.94		SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59
+	Hs
		1056974 MDC1_HUMAN (304-1327): 2.36e-23: 110: 10.94		WDR33_HUMAN (198-342): 2.09e-17: 88.1: 10.67
+	Hs
		1281391 PRR36_HUMAN (3-990): 8.54e-24: 111: 12.75		FBXW7_HUMAN (279-521): 2.8e-16: 83.9: 10.56
+	Sp
		224208 CYC8_SCHPO (16-442): 3.12e-28: 126: 12.70		TUP12_SCHPO (226-339): 4.64e-10: 64.3: 18.33
+	Sp
		224207 CYC8_SCHPO (16-442): 3.12e-28: 126: 12.70		TUP11_SCHPO (2-58): 7.11e-09: 60.4: 14.04
+	Hs
		903405 CBP_HUMAN (35-1003): 1.04e-25: 118: 11.05		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41
+	Hs
		297832 K0754_HUMAN (4-374): 4.59e-15: 83.5: 14.29		BRWD3_HUMAN (228-450): 4.8e-15: 80.8: 12.86