HitPredict

Interactor 1: KDM6B (O15054)
Lysine-specific demethylase 6B (EC 1.14.11.68) (JmjC domain-containing protein 3) (Jumonji domain-containing protein 3) (Lysine demethylase 6B) ([histone H3]-trimethyl-L-lysine(27) demethylase 6B)
Gene: KDM6B

Interactor 2: CBP (Q92793)
CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-)
Gene: CREBBP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	32238831
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031490 - chromatin DNA binding GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1643 Hs			1 2442
+	Hs
		183144 KDM6A_HUMAN (1-647): 1.77e-50: 199: 14.24		CBP_HUMAN (1-2442): 0: 1104: 100.00
+	Hs
		1270755 CBP_HUMAN (35-1003): 1.04e-25: 118: 11.05		CBP_HUMAN (1-2442): 0: 1104: 100.00
+	Hs
		1056910 MDC1_HUMAN (304-1327): 2.36e-23: 110: 10.94		CBP_HUMAN (1-2442): 0: 1104: 100.00
+	Mm
		70879 EP300_MOUSE (26-1033): 9.84e-31: 135: 8.89		F8VPR5_MOUSE (1-2442): 0: 1077: 95.67
+	Hs
		554303 MUC1_HUMAN (35-953): 7.96e-51: 199: 12.61		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		998940 CBP_HUMAN (35-1003): 1.04e-25: 118: 11.05		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		998710 MDC1_HUMAN (304-1327): 2.36e-23: 110: 10.94		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Dm
		114481 M9PCJ7_DROME (1-249): 1.94e-30: 133: 17.10		M9PH39_DROME (480-2357): 0: 829: 35.44
+	Hs
		999222 SRRM2_HUMAN (324-1330): 8.25e-13: 76.1: 10.52		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		554259 MUC1_HUMAN (35-953): 7.96e-51: 199: 12.61		MUC1_HUMAN (1947-2441): 7.35e-18: 93.3: 11.02
+	Hs
		150104 UTY_HUMAN (1-588): 2.61e-53: 208: 14.15		KMT2C_HUMAN (1945-2437): 8.84e-10: 67.1: 13.89
+	Hs
		183137 KDM6A_HUMAN (1-647): 1.77e-50: 199: 14.24		KMT2C_HUMAN (1945-2437): 8.84e-10: 67.1: 13.89
+	Hs
		1057027 MDC1_HUMAN (304-1327): 2.36e-23: 110: 10.94		TRI33_HUMAN (694-1207): 3.25e-37: 156: 14.83
+	Hs
		170437 CBP_HUMAN (35-1003): 1.04e-25: 118: 11.05		TIF1A_HUMAN (667-1202): 2.17e-34: 147: 17.97
+	Hs
		1056838 MDC1_HUMAN (304-1327): 2.36e-23: 110: 10.94		BRD3_HUMAN (1073-1195): 1.36e-33: 143: 30.89
+	Hs
		631425 MDC1_HUMAN (304-1327): 2.36e-23: 110: 10.94		BRD2_HUMAN (1065-1195): 9.64e-34: 143: 30.53
+	Dm
		113976 M9PB30_DROME (689-1370): 1.78e-19: 98.5: 9.00		M9PB30_DROME (244-1120): 3.23e-21: 104: 9.85
+	Mm
		1351630 PCLO_MOUSE (4-1294): 6.97e-28: 125: 10.38		PCLO_MOUSE (1831-2420): 5.14e-13: 77.5: 10.91
+	Sc
		542149 CYC8_YEAST (23-730): 3.43e-28: 125: 9.87		GCN5_YEAST (1110-1192): 5.75e-12: 72.4: 37.35