HitPredict

Interactor 1: DCLK1 (O15075)
Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1)
Gene: DCLK1

Interactor 2: AFAD (P55196)
Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)
Gene: AFDN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27173435
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FHA~Pkinase
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 740 Hs			1 1824
+	Hs
		166615 DCLK1_HUMAN (1-740): 0: 896: 100.00		KI13B_HUMAN (184-691): 5.1e-66: 250: 12.64
+	Hs
		166629 DCLK1_HUMAN (1-740): 0: 896: 100.00		NEB1_HUMAN (1002-1092): 1.04e-19: 98.7: 40.00
+	Hs
		1234199 DCLK2_HUMAN (1-725): 0: 801: 66.22		NEB1_HUMAN (1002-1092): 1.04e-19: 98.7: 40.00
+	Hs
		231684 KCC1G_HUMAN (373-727): 4.38e-127: 388: 35.96		KIF1B_HUMAN (191-589): 6.21e-42: 171: 15.66
+	Mm
		292336 DCX_MOUSE (6-359): 2.77e-137: 410: 69.89		DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51
+	Hs
		1050040 M3K3_HUMAN (51-646): 5.47e-139: 424: 18.59		SCRIB_HUMAN (989-1133): 4.27e-22: 106: 26.85
+	Mm
		1143346 KCC2D_MOUSE (385-737): 1.46e-130: 398: 33.05		DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51
+	Mm
		1143553 KS6A2_MOUSE (388-680): 2.2e-99: 324: 27.24		DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51
+	Mm
		515234 KCC2A_MOUSE (387-648): 1.01e-64: 224: 42.48		DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51
+	Mm
		1131547 Q5SVI3_MOUSE (387-647): 4.1e-63: 221: 43.77		DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51
+	Mm
		659457 KCC2B_MOUSE (387-647): 3.22e-62: 219: 43.77		DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51
+	Hs
		1271040 KCC2A_HUMAN (387-648): 1.19e-64: 224: 42.48		DLG3_HUMAN (1009-1467): 4.67e-23: 109: 13.25
+	Rn
		506776 KCC2A_RAT (387-648): 1.01e-64: 224: 42.48		MYO5A_RAT (1409-1824): 4.91e-17: 90: 14.59
+	Rn
		506744 KCC2A_RAT (387-648): 1.01e-64: 224: 42.48		DLG3_RAT (1010-1232): 3.36e-13: 77.2: 20.08
+	Mm
		515236 KCC2A_MOUSE (387-648): 1.01e-64: 224: 42.48		INADL_MOUSE (926-1089): 7.2e-11: 69.8: 20.54
+	Mm
		659459 KCC2B_MOUSE (387-647): 3.22e-62: 219: 43.77		INADL_MOUSE (926-1089): 7.2e-11: 69.8: 20.54