HitPredict

Interactor 1: DCLK1 (O15075)
Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1)
Gene: DCLK1

Interactor 2: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	36931259
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006468 - protein phosphorylation GO:1900181 - negative regulation of protein localization to nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 740 Hs			1 245
+	Hs
		166549 DCLK1_HUMAN (1-740): 0: 896: 100.00		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		166534 DCLK1_HUMAN (1-740): 0: 896: 100.00		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		166539 DCLK1_HUMAN (1-740): 0: 896: 100.00		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Mm
		910345 DCLK1_MOUSE (1-740): 0: 883: 96.43		1433E_MOUSE (2-241): 9.9e-144: 403: 68.18
+	Hs
		166546 DCLK1_HUMAN (1-740): 0: 896: 100.00		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		166554 DCLK1_HUMAN (1-740): 0: 896: 100.00		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49
+	Hs
		909811 DCLK2_HUMAN (1-725): 0: 801: 66.22		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Mm
		910275 DCLK2_MOUSE (1-737): 0: 799: 66.14		1433E_MOUSE (2-241): 9.9e-144: 403: 68.18
+	Hs
		647105 DCLK2_HUMAN (1-725): 0: 801: 66.22		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		683540 DCLK2_HUMAN (1-725): 0: 801: 66.22		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		904852 DCLK2_HUMAN (1-725): 0: 801: 66.22		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		982272 DCLK2_HUMAN (1-725): 0: 801: 66.22		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49
+	Hs
		684207 DCLK2_HUMAN (1-725): 0: 801: 66.22		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97
+	Ce
		785031 DCLK_CAEEL (55-695): 0: 549: 36.56		14331_CAEEL (5-238): 1.78e-111: 322: 79.49
+	Hs
		927454 M3K3_HUMAN (51-646): 5.47e-139: 424: 18.59		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		909957 M3K3_HUMAN (51-646): 5.47e-139: 424: 18.59		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		647221 M3K3_HUMAN (51-646): 5.47e-139: 424: 18.59		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		683663 M3K3_HUMAN (51-646): 5.47e-139: 424: 18.59		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		905036 M3K3_HUMAN (51-646): 5.47e-139: 424: 18.59		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		982424 M3K3_HUMAN (51-646): 5.47e-139: 424: 18.59		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49